OGT

4 papers2 findings

HGNC NCBI Gene Taxon

2 independent labs in 2 countries

Funder: National Institute of Diabetes and Digestive and Kidney Diseases

Animals1
Cells3

Interventions

1

Phenformin

downin human cells1

1 study

Phenformin decreases OGT in human cells.
“phenformin reduced expression of O-linked N-acetylglucosamine (O-GlcNAc) transferase, lowering global O-GlcNAcylation”
Cellsin HeLa cells
O-GlcNAcylation is a mitochondrial-nuclear signal that regulates passive transport through the nuclear pore complex
The Journal of biological chemistry16 Jul 2026

More on Phenformin

Effects

1

LEP O-GlcNAcylation

upin mouse cells1

1 study

OGT increases LEP O-GlcNAcylation in mouse cells.
“Furthermore, OGT was found to promote O-GlcNAcylation of LEP at the S50 site.”
CellsAt the LEP S50 siteC3H10T1/2
LEP O-GlcNAcylation inactivates NF-κB pathway by suppressing LEP protein level and thus mediates cellular senescence and osteogenic differentiation in mouse mesenchymal stem cells
BMC molecular and cell biology18 Dec 2024

Latest

2 in 12 months

The Journal of Biological Chemistry17 Jul

O-GlcNAcylation is a mitochondrial-nuclear signal that regulates passive transport through the nuclear pore complex

Experiments in human cellsMitochondrion

Biology of Reproduction11 May

O-GlcNAcylation of p66Shc drives senescence-associated secretory phenotype via mitochondrial DNA release in gestational diabetes mellitus†

Experiments in human cellsSenescence-associated secretory phenotype (SASP)

Diabetes, Metabolic Syndrome and Obesity23 Oct

Topical Application of miR-200b-3p by Poloxamer 407-Based Hydrogel Accelerates Diabetic Wound Healing

Experiments in miceSkin

BMC Molecular and Cell Biology19 Dec

LEP O-GlcNAcylation inactivates NF-κB pathway by suppressing LEP protein level and thus mediates cellular senescence and osteogenic differentiation in mouse mesenchymal stem cells

Experiments in mouse cellsStem cell differentiation