Neonatal overfeeding

Intervention

1 paper2 findings

  • 1 lab in 1 country
  • Funders: National Natural Science Foundation of China and 1 more
  • Animals1

Outcomes

2

Age-related sarcopenia

upin mice1

1 study
  1. Neonatal overfeeding increases age-related sarcopenia in mice.

    “Here, we show that neonatal overfeeding acts as a developmental insult that accelerates age-related sarcopenia in both sexes.”

    Animalsskeletal muscle

    Early overfeeding speeds muscle loss and shortens life in mice

    Nature communications7 Oct 2026

More on Age-related sarcopenia

Lifespan

downin mice1

1 study
  1. Neonatal overfeeding shortens lifespan in mice.

    “Using different mouse models, early overnutrition shortens lifespan and exacerbates late-life muscle atrophy, accompanied by metabolic dysfunction.”

    Animals

    Early overfeeding speeds muscle loss and shortens life in mice

    Nature communications7 Oct 2026

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Nature Communications

Early overfeeding speeds muscle loss and shortens life in mice

Overfeeding young mice damaged gut microbes, impaired muscle cell energy production, and worsened age-related muscle wasting in later life.Overfeeding young mice damaged gut microbes, impaired muscle cell energy production, and worsened age-related muscle wasting in later life.

Experiments in miceMuscle