Myriocin

1. Myriocin increases fatty acid β-oxidation in mice.

   “Myriocin increased fatty acid utilization compared to control diet and chow, and showed an increasing trend relative to Western diet, with no differences in energy expenditure.”

   Animalsin aged mice fed a Western dietintermittently (one week on, two weeks off)

   Ceramide-Lowering Therapy Improves Metabolic Health in Aged UM-HET3 Mice Fed a Western Diet · GSA 2025 abstract · 31 Dec 2025

Fatty acid β-oxidation →

1. Myriocin improves oxidative phosphorylation in mice.

   “Liver mitochondrial function assessed by high-resolution respirometry was negatively impacted by Western diet and partially rescued by myriocin.”

   Animalsin aged mice fed a Western dietliverintermittently (one week on, two weeks off)

   Ceramide-Lowering Therapy Improves Metabolic Health in Aged UM-HET3 Mice Fed a Western Diet · GSA 2025 abstract · 31 Dec 2025

Oxidative phosphorylation →

1. Myriocin decreases body fat percentage in mice.

   “Body composition by qMRI showed reduced body fat percentage with myriocin.”

   Animalsin aged mice fed a Western dietintermittently (one week on, two weeks off)

   Ceramide-Lowering Therapy Improves Metabolic Health in Aged UM-HET3 Mice Fed a Western Diet · GSA 2025 abstract · 31 Dec 2025

Body fat percentage →

1. Myriocin improves glucose tolerance in mice.

   “Oral Glucose tolerance tests (OGTT), blood lactate and ketones, indicated that myriocin restored glucose tolerance to control diet levels, without affecting lactate or ketones.”

   Animalsin aged mice fed a Western dietintermittently (one week on, two weeks off)

   Ceramide-Lowering Therapy Improves Metabolic Health in Aged UM-HET3 Mice Fed a Western Diet · GSA 2025 abstract · 31 Dec 2025

1. Myriocin extends lifespan in mice.

   “In addition, preliminary data suggests that myriocin significantly extends lifespan in mice as well.”

   Animals

   EVIDENCE SUPPORTING CERAMIDE ACCUMULATION AS A NOVEL HALLMARK OF AGING · GSA 2024 abstract · 31 Dec 2024

1. Myriocin improves grip strength in mice.

   “low doses of myriocin, a potent inhibitor of ceramide synthesis, improves healthspan (i.e. glucose homeostasis and grip strength) in WT C57BL/6J, Balb/c, and UM-HET3 mice fed with Western diet.”

   Animalsfed with Western dietlow doses

   EVIDENCE SUPPORTING CERAMIDE ACCUMULATION AS A NOVEL HALLMARK OF AGING · GSA 2024 abstract · 31 Dec 2024