REVERSING INSULIN RESISTANCE AND SARCOPENIA BY LOWERING TOXIC CERAMIDES IN OBESE NONHUMAN PRIMATES

Abstract

Obese and old individuals are at heightened risk of developing insulin resistance, sarcopenia, and frailty. Specifically, we found that older obese men experience a diminished capacity to synthesize new muscle proteins in response to exogenous amino acids, a process pivotal for the maintenance of muscle mass and quality.