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MSDC-0160

MSDC-0160 has been studied in 1 paper since 2026: none in people yet, 1 in animals; 1 in the past year. The research so far is in animals. The newest story, Nov 9, 2026: “Blocking a fuel carrier may reduce kidney scarring in mice”.

Intervention

1 paper studies it4 findingsUpdated

PubChemChEBI

1 new paper in 30 daysSee all 1 papers on MSDC-0160

At a glance

The findings reach mice, none yet in people. 1 lab; 2 trials, none about aging.

None of its findings points the other way.

Mice: a single group. Cells, worms or flies and humans: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

About aging: the drug’s trials about aging. The total counts its trials for every use.

  • 1 lab
  • 2 trials, none about aging
  • 2 of 2 trials sponsored by its developers
  • Animals1

What did studies of MSDC-0160 find?

4

Studies of MSDC-0160 measured 4 outcomes, among them mitophagy, mitochondrial respiration and fatty acid oxidation-related gene expression.

Mitophagy

upin mice1

1 study

  1. MSDC-0160 increases mitophagy in mice (mito-QC reporter mice).

    “Increased mitochondrial respiration is linked to enhanced mitophagy, which was confirmed in mito-QC mice treated with MSDC-0160.”

    Animalsmito-QC reporter micekidney

    Blocking a fuel carrier may reduce kidney scarring in mice

    AHA Scientific Sessions 2026 abstract

More on Mitophagy

Mitochondrial respiration

upin mice1

1 study

  1. MSDC-0160 increases mitochondrial respiration in mice.

    “Functionally, MSDC-0160-treated kidney tissue had increased mitochondrial respiration”

    Animalskidney

    Blocking a fuel carrier may reduce kidney scarring in mice

    AHA Scientific Sessions 2026 abstract

Fatty acid oxidation-related gene expression

upin mice1

1 study

  1. MSDC-0160 increases fatty acid oxidation-related gene expression in mice (aging).

    “MSDC-0160 decreased fibrosis and restored gene expression of FAO related genes.”

    Animalsagingkidney

    Blocking a fuel carrier may reduce kidney scarring in mice

    AHA Scientific Sessions 2026 abstract

More on Fatty acid oxidation-related gene expression

Kidney fibrosis

downin mice1

1 study

  1. MSDC-0160 decreases kidney fibrosis in mice (aging).

    “MSDC-0160 decreased fibrosis and restored gene expression of FAO related genes.”

    Animalsagingkidney

    Blocking a fuel carrier may reduce kidney scarring in mice

    AHA Scientific Sessions 2026 abstract

Latest

Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 0Nov 2026: 11 paper in 12 months
AHA Scientific Sessions 2026 Abstract

Blocking a fuel carrier may reduce kidney scarring in mice

In experiments with 22-month-old mice, a drug reduced kidney scarring and restored activity of genes involved in using fat for energy.In experiments with 22-month-old mice, a drug reduced kidney scarring and restored activity of genes involved in using fat for energy.

Mouse studyKidney
Paper

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