Moderate-protein diet

Moderate-protein diet has been studied in 5 papers since 2016: 4 trials in people, 1 in animals; 1 in the past year. The newest paper, Nov 3, 2026: “Exploratory serum renal biomarker and eGFR responses to high-protein diets during resistance versus concurrent training in resistance-trained men”.

Intervention

5 papers study it3 findingsUpdated

1 new paper in 30 daysSee all 5 papers on moderate-protein diet

At a glance

The findings reach people, from one lab or study. 2 independent labs in 2 countries.

“MyoPS in the HIGH condition remained constant (P = 1.000), but MOD decreased over time (P = 0.023).”
Early resistance training-mediated stimulation of daily muscle protein synthetic responses to higher habitual protein intake in middle-aged adultsThe Journal of physiology2021doi:10.1113/jp281907

None of its findings points the other way.

Mice and humans: a single group. Cells and worms or flies: nothing yet.
  • 2 independent labs in 2 countries
  • Funders: Bio-oriented Technology Research Advancement Institution and 1 more
  • 2 of 3 findings with company ties
  • Human trial4
  • Animals1

Studies in people

1 study gave moderate-protein diet to people and measured what changed.

What changedDesignPeopleSource

down: Decreases myofibrillar protein synthesis rateP = 0.023

Trial3 weeks20 peopleBoth47 ± 1 yearsMidlife adults; during resistance trainingThe Journal of physiology, Jul 29, 2021

What did studies of moderate-protein diet find?

3

Studies of moderate-protein diet measured 3 outcomes: lipids, blood glucose and myofibrillar protein synthesis rate.

Lipids

downin mice1

1 study
  1. Moderate-protein diet decreases lipids in mice (isocaloric diet with varying protein percentages).

    “whereas the moderate-protein diet suppressed lipid contents and lowered the levels of blood glucose and lipids.”

    Animalsisocaloric diet with varying protein percentagestwo months

    Moderate protein intake percentage in mice for maintaining metabolic health during approach to old age

    GeroScience

More on Lipids

Blood glucose

downin mice1

1 study
  1. Moderate-protein diet decreases blood glucose in mice (isocaloric diet with varying protein percentages).

    “whereas the moderate-protein diet suppressed lipid contents and lowered the levels of blood glucose and lipids.”

    Animalsisocaloric diet with varying protein percentagestwo months

    Moderate protein intake percentage in mice for maintaining metabolic health during approach to old age

    GeroScience

More on Blood glucose

Myofibrillar protein synthesis rate

downin humans1

1 study
  1. Moderate-protein diet decreases myofibrillar protein synthesis rate in humans during resistance training (P = 0.023).

    “MyoPS in the HIGH condition remained constant (P = 1.000), but MOD decreased over time (P = 0.023).”

    Human trialduring resistance trainingskeletal muscle1.06 ± 0.22 g kg−1 day−13 weeksn = 20

    Early resistance training-mediated stimulation of daily muscle protein synthetic responses to higher habitual protein intake in middle-aged adults

    The Journal of physiology

More on Myofibrillar protein synthesis rate

Latest

Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 0Nov 2026: 11 paper in 12 months