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Maternal smoking during pregnancy

Exposure

3 papers8 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 3 independent labs in 2 countries
  • Funders: National Natural Science Foundation of China and 3 more
  • Humans3

Outcomes

3

KDM biological age

upin humans1

1 study

  1. Maternal smoking during pregnancy increases KDM biological age in humans (β = 0.100, 95% CI 0.018-0.181).

    “The KDM age increased by 0.100 due to MSDP (β = 0.100,95 % CI:0.018-0.181)”

    Humans

    Maternal smoking during pregnancy could accelerate aging in the adulthood: evidence from a perspective study in UK Biobank

    The Science of the total environmentJul 30, 2024

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Telomere length

downin humans1

1 study

  1. Maternal smoking during pregnancy decreases telomere length in humans (-0.8%, β = -0.008, 95% CI -0.009 to -0.006).

    “offspring of the MSDP group had significantly shorter telomere length in adulthood by 0.8 % (β = -0.008,95%CI:-0.009 to -0.006)”

    Humans

    Maternal smoking during pregnancy could accelerate aging in the adulthood: evidence from a perspective study in UK Biobank

    The Science of the total environmentJul 30, 2024

More on Telomere length

Lifespan

downin humans1

1 study

  1. Maternal smoking during pregnancy shortens lifespan in humans.

    “MSDP was associated with an increased risk of all-cause mortality and reduced life expectancy”

    Humansmedian follow-up of 12.47 years

    Associations of maternal and personal smoking with all-cause and cause-specific mortality risk and life expectancy: a prospective cohort study

    Public healthMar 4, 2024

Associations

4

Mortality

upin humans2HR 1.12–1.122

2 studies

  1. Maternal smoking during pregnancy raises the risk of mortality in humans (+12.2%, HR = 1.122, 95% CI 1.064-1.182).

    “MSDP group had a 12.2 % increased risk of all-cause premature mortality (HR = 1.122,95%CI:1.064-1.182)”

    Humans

    Maternal smoking during pregnancy could accelerate aging in the adulthood: evidence from a perspective study in UK Biobank

    The Science of the total environmentJul 30, 2024

  2. Maternal smoking during pregnancy raises the risk of mortality in humans (HR 1.12, 95% CI 1.09-1.15).

    “MSDP elevated the risk of all-cause mortality (HR = 1.12, 95% CI: 1.09-1.15)”

    Humansmedian follow-up of 12.47 years

    Associations of maternal and personal smoking with all-cause and cause-specific mortality risk and life expectancy: a prospective cohort study

    Public healthMar 4, 2024

Lung cancer

upin humans1HR 1.554

1 study

  1. Maternal smoking during pregnancy raises the risk of lung cancer in humans (+55.4%, HR = 1.554, 95% CI 1.346-1.793).

    “significant risk of lung cancer-specific premature mortality increased by 55.4 %(HR = 1.554,95%CI:1.346-1.793)”

    Humans

    Maternal smoking during pregnancy could accelerate aging in the adulthood: evidence from a perspective study in UK Biobank

    The Science of the total environmentJul 30, 2024

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Age-related hospitalization rate

upin humans1HR 1.104

1 study

  1. Maternal smoking during pregnancy raises the risk of age-related hospitalization rate in humans (+10.4%, HR = 1.104, 95% CI 1.066-1.144).

    “risk of aging-related hospitalizations was significantly higher than the non-MSDP group by 10.4 %(HR = 1.104,95%CI:1.066-1.144)”

    Humans

    Maternal smoking during pregnancy could accelerate aging in the adulthood: evidence from a perspective study in UK Biobank

    The Science of the total environmentJul 30, 2024

Stroke

upin humans1HR 1.11

1 study

  1. Maternal smoking during pregnancy raises the risk of stroke in humans (HR: 1.11, 95% CI: 1.05-1.18, P < 0.001).

    “participants whose mothers smoked during pregnancy showed an 11% increased risk of stroke (HR: 1.11, 95% CI: 1.05-1.18, P < 0.001)”

    Humansmaternal smoking during pregnancy

    Early-life tobacco smoke exposure and stroke risk: a prospective study of 341,783 and 352,737 UK Biobank participants

    BMC public healthMay 17, 2024

More on Stroke

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