Maslinic acid
- 1 lab in 1 country
- Funders: Basic and Applied Basic Research Foundation of Guangdong Province and 2 more
- Animals1
Outcomes
5NF-κB signalling
downin rat cells1
1 study
NF-κB signalling
downin rat cells1
Maslinic acid inhibits NF-κB signalling in rat cells.
“MA significantly affects the PI3K/AKT and NF-κB pathways in TNFα-induced NPCs”
CellsTNFα-induced nucleus pulposus cellsnucleus pulposus
Acta biochimica et biophysica Sinica18 Mar 2024
PI3K–AKT signalling
downin rat cells1
1 study
PI3K–AKT signalling
downin rat cells1
Maslinic acid inhibits PI3K–AKT signalling in rat cells.
“MA significantly affects the PI3K/AKT and NF-κB pathways in TNFα-induced NPCs”
CellsTNFα-induced nucleus pulposus cellsnucleus pulposus
Acta biochimica et biophysica Sinica18 Mar 2024
Intervertebral disc degeneration
downin rats1
1 study
Intervertebral disc degeneration
downin rats1
Maslinic acid protects against intervertebral disc degeneration in rats.
“It can also impede the progression of IDD in rats.”
Animals
Acta biochimica et biophysica Sinica18 Mar 2024
Extracellular matrix remodelling
upin rat cells1
1 study
Extracellular matrix remodelling
upin rat cells1
Maslinic acid improves extracellular matrix remodelling in rat cells.
“upregulating aggrecan and collagen II levels as well as downregulating MMP and ADAMTS levels in nucleus pulposus cells (NPCs)”
CellsTNFα-induced nucleus pulposus cellsnucleus pulposus
Acta biochimica et biophysica Sinica18 Mar 2024
Cellular senescence
downin rat cells1
1 study
Cellular senescence
downin rat cells1
Maslinic acid decreases cellular senescence in rat cells.
“MA ameliorates the imbalance of the extracellular matrix (ECM) and mitigates senescence”
CellsTNFα-induced nucleus pulposus cellsnucleus pulposus
Acta biochimica et biophysica Sinica18 Mar 2024