Madecassoside

1. Madecassoside inhibits MAPK/ERK signalling in human cells.

   Cellsin D-galactose-treated HK-2 cells

   The active ingredient madecassoside in Huyan no. 1 formula ameliorates D-gal-induced renal aging through the AMPK/MAPK/AP-1 signaling pathway · International immunopharmacology · 3 Sep 2026

MAPK/ERK signalling →

1. Madecassoside improves mitochondrial function in human cells.

   Cellsin D-galactose-treated HK-2 cells

   The active ingredient madecassoside in Huyan no. 1 formula ameliorates D-gal-induced renal aging through the AMPK/MAPK/AP-1 signaling pathway · International immunopharmacology · 3 Sep 2026

1. Madecassoside decreases intracellular peroxide accumulation in human cells.

   Cellsin D-galactose-treated HK-2 cells

   The active ingredient madecassoside in Huyan no. 1 formula ameliorates D-gal-induced renal aging through the AMPK/MAPK/AP-1 signaling pathway · International immunopharmacology · 3 Sep 2026

Intracellular peroxide accumulation →

1. Madecassoside decreases senescence-associated secretory phenotype (SASP) in mice.

   Animalsin D-galactose-treated miceserum

   The active ingredient madecassoside in Huyan no. 1 formula ameliorates D-gal-induced renal aging through the AMPK/MAPK/AP-1 signaling pathway · International immunopharmacology · 3 Sep 2026

Senescence-associated secretory phenotype (SASP) →

1. Madecassoside decreases renal pathological injury in mice.

   Animalsin D-galactose-treated mice

   The active ingredient madecassoside in Huyan no. 1 formula ameliorates D-gal-induced renal aging through the AMPK/MAPK/AP-1 signaling pathway · International immunopharmacology · 3 Sep 2026