bioRxiv
Statins plus an immune-cell molecule killed kidney cells
In kidney cell experiments, atorvastatin and fluvastatin caused cell death when combined with 25-hydroxycholesterol, a cholesterol derivative made by activated immune…In kidney cell experiments, atorvastatin and fluvastatin caused cell death when combined with 25-hydroxycholesterol, a cholesterol derivative made by activated immune cells.
Preprint: cell studyKidney
Who was studiedProximal tubular cells, mice, and human kidney organoids
What changedAtorvastatin and fluvastatin combined with an immune-cell cholesterol derivative caused death in proximal tubular kidney cells
The catchThe kidney organoid result used KIM-1 expression as a stand-in for kidney injury