25-hydroxycholesterol

1. 25-hydroxycholesterol induces senolysis in human cells.

   “We then validated 25HC as a senolytic in mouse and human cells in culture and in vivo in mouse skeletal muscle.”

   Cellscells in culture

   Senolysis induced by 25-hydroxycholesterol targets CRYAB in multiple cell types

   iScience·Feb 2, 2022

2. 25-hydroxycholesterol induces senolysis in mouse cells.

   “We then validated 25HC as a senolytic in mouse and human cells in culture and in vivo in mouse skeletal muscle.”

   Cellscells in culture

   Senolysis induced by 25-hydroxycholesterol targets CRYAB in multiple cell types

   iScience·Feb 2, 2022

1. 25-hydroxycholesterol decreases Cryab in mice.

   “25HC suppressed its putative molecular target CRYAB”

   Animals5d

   Late Life Supplementation of 25-Hydroxycholesterol Reduces Aortic Stiffness and Cellular Senescence in Mice

   Aging cell·May 22, 2025

More on Cryab

1. 25-hydroxycholesterol decreases cellular senescence in mice.

   “25HC suppressed its putative molecular target CRYAB, modulated CRYAB-regulated senescent cell anti-apoptotic pathways, and reduced markers of cellular senescence”

   Animals5d

   Late Life Supplementation of 25-Hydroxycholesterol Reduces Aortic Stiffness and Cellular Senescence in Mice

   Aging cell·May 22, 2025

More on Cellular senescence

1. 25-hydroxycholesterol decreases aortic stiffness in mice (p = 0.002).

   “short-term (5d) treatment with 25HC reduced aortic stiffness in vivo, assessed via aortic pulse wave velocity (p = 0.002)”

   Animals5d

   Late Life Supplementation of 25-Hydroxycholesterol Reduces Aortic Stiffness and Cellular Senescence in Mice

   Aging cell·May 22, 2025