Mevalonate

Intervention

1 paper studies it1 finding

Across all fields, 1 paper: none in people yet, 1 in animals

  • 1 lab in 1 country
  • Animals1

Outcomes

1

Acylcarnitines

upin mice1

1 study
  1. Mevalonate increases acylcarnitines in mice.

    “mevalonate treatment did not rescue the phenotype and increased the levels of several acylcarnitine species.”

    Animalswhole-body Hmgcr-knockout mice

    Drug improved survival in mice missing the enzyme statins target

    Research SquarePreprint

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Research Square

Drug improved survival in mice missing the enzyme statins target

In a mouse experiment, the compound also prevented low blood sugar and reduced liver injury after loss of the enzyme blocked by statins.In a mouse experiment, the compound also prevented low blood sugar and reduced liver injury after loss of the enzyme blocked by statins.

Preprint: mouse studyMechanisms