Luteolin

Intervention Phase 2

2 papers6 findings

PubChem 5280445 ChEBI 15864 MeSH D047311

Adult luteolin supplementation extends lifespan, improves locomotor activity and activates autophagy in female flies, whereas embryonic exposure shortens lifespan. All 4 findings come from one lab, without independent replication. The National Natural Science Foundation of China, Universidade de Vigo and Xunta de Galicia are each named as funders across all 4 findings.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 2 countries
1 finding against
2 trials, 1 with no results posted

Funders: National Natural Science Foundation of China and 2 more

Model organisms2

Outcomes

5

Lifespan

downin flies1upin flies1+12%

1 study

Luteolin shortens lifespan in flies.
Model organismsembryonic exposure
Luteolin promotes healthy aging in adult females but shortens lifespan after embryonic exposure in Drosophila melanogaster
Frontiers in nutrition20 Aug 2026
Luteolin extends lifespan in flies (+11.6%).
Model organismsadult supplementationfemales
Luteolin promotes healthy aging in adult females but shortens lifespan after embryonic exposure in Drosophila melanogaster
Frontiers in nutrition20 Aug 2026

Autophagy

upin flies1

1 study

Luteolin activates autophagy in flies.
Model organismsadult supplementationfemales
Luteolin promotes healthy aging in adult females but shortens lifespan after embryonic exposure in Drosophila melanogaster
Frontiers in nutrition20 Aug 2026

More on Autophagy

Locomotor activity

upin flies1

1 study

Luteolin improves locomotor activity in flies.
Model organismsadult supplementationfemales
Luteolin promotes healthy aging in adult females but shortens lifespan after embryonic exposure in Drosophila melanogaster
Frontiers in nutrition20 Aug 2026

Sarcopenia

downin worms1

1 study

Luteolin decreases sarcopenia in worms.
Model organismsin aged nematodes
Luteolin and glycitein from Codonopsis pilosula ameliorate age-related locomotor decline in C. elegans via DAF-16-dependent but autophagy-divergent pathways
Biogerontology13 Aug 2026

More on Sarcopenia

Locomotor decline

downin worms1

1 study

Luteolin decreases locomotor decline in worms.
Model organisms
Luteolin and glycitein from Codonopsis pilosula ameliorate age-related locomotor decline in C. elegans via DAF-16-dependent but autophagy-divergent pathways
Biogerontology13 Aug 2026

Trials

2

In trials

Autism spectrum disorder
Phase 2Completed1 trial
Carcinoma
Early phase 1Status unknown1 trial

Trial sponsors

Attikon Hospital
1 trialPhase 250 people
Cairo University
1 trialEarly phase 14 people

Latest

4 in 12 months

Nutrients15 Sep

Bioactive Phytochemicals from Artocarpus integer Leaves Improve Bone-Related Outcomes in Ovariectomized Rats: An Integrated LC-HRMS, Network Pharmacology, and Experimental Study

Experiments in ratsBones and joints

Journal of Ethnopharmacology4 Sep

Synaptic remodeling and functional recovery: Huan Le Ning decoction mitigates perimenopausal anxiety and depression symptoms via hippocampal reorganization

Experiments in miceAnxiety

Frontiers in Nutrition4 Sep

Luteolin promotes healthy aging in adult females but shortens lifespan after embryonic exposure in Drosophila melanogaster

Experiments in fliesInterventions

Biogerontology13 Aug

Luteolin and glycitein from Codonopsis pilosula ameliorate age-related locomotor decline in C. elegans via DAF-16-dependent but autophagy-divergent pathways

Experiments in wormsInterventions