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Loxenatide

Loxenatide has been studied in 2 papers since 2023: none in people yet, 2 in cells. No study of it in people or animals has been published yet. The newest paper, Sep 27, 2024: “Loxenatide Alleviates High Glucose-Induced Pancreatic β-Cell Senescence via Regulating the PERK/eIF2α Pathway”.

Intervention

2 papers study it6 findingsUpdated

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C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funder: Health Commission of Hebei Province
  • Cells2

What did studies of Loxenatide find?

6

Studies of Loxenatide measured 6 outcomes; the most studied are insulin secretion (1 study), cellular senescence (1) and sirtuin signaling (1).

Insulin secretion

upin cells1

1 study

  1. Loxenatide increases insulin secretion in cells.

    “HG induction resulted in promoted insulin secretion and insulin synthesis of pancreatic β-cells and loxenatide treatment further strengthened these influences.”

    Cellsin high glucose-induced pancreatic β-cells

    Loxenatide Alleviates High Glucose-Induced Pancreatic β-Cell Senescence via Regulating the PERK/eIF2α Pathway

    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme

More on Insulin secretion

Cellular senescence

downin cells1

1 study

  1. Loxenatide inhibits cellular senescence in cells.

    “loxenatide impeded cellular senescence, promoted cell proliferation, improved DNA damage, enhanced insulin secretion and insulin synthesis of HG-induced pancreatic β-cells through modulating the PERK/eIF2α signaling pathway.”

    Cellsin high glucose-induced pancreatic β-cells

    Loxenatide Alleviates High Glucose-Induced Pancreatic β-Cell Senescence via Regulating the PERK/eIF2α Pathway

    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme

More on Cellular senescence

Sirtuin signaling

upin cells1

1 study

  1. Loxenatide activates sirtuin signaling in cells.

    “The protection effect of Loxenatide on EPCs against high-glucose was applied by activating the sirtuin 3 (SIRT3)/Foxo3 signaling pathway”

    Cellsin EPCs against high-glucose

    Loxenatide attenuates ROS-mediated vascular endothelial progenitor cell damage and mitochondrial dysfunction via SIRT3/Foxo3 signaling pathway

    Journal of biochemical and molecular toxicology

More on Sirtuin signaling

Mitochondrial respiration dysfunction

downin cells1

1 study

  1. Loxenatide decreases mitochondrial respiration dysfunction in cells.

    “EPC mitochondrial respiration dysfunction induced by high glucose was also repressed by the loxenatide treatment”

    Cellshigh-glucose-induced

    Loxenatide attenuates ROS-mediated vascular endothelial progenitor cell damage and mitochondrial dysfunction via SIRT3/Foxo3 signaling pathway

    Journal of biochemical and molecular toxicology

Apoptosis

downin cells1

1 study

  1. Loxenatide inhibits apoptosis in cells.

    “mitochondrial-dependent apoptosis of EPCs in a concentration-dependent manner”

    Cellshigh-glucose-induced

    Loxenatide attenuates ROS-mediated vascular endothelial progenitor cell damage and mitochondrial dysfunction via SIRT3/Foxo3 signaling pathway

    Journal of biochemical and molecular toxicology

More on Apoptosis

Oxidative stress and ROS signaling

downin cells1

1 study

  1. Loxenatide decreases oxidative stress and ROS signaling in cells.

    “Loxenatide attenuated high-glucose-induced reactive oxygen species (ROS) production”

    Cellshigh-glucose-induced

    Loxenatide attenuates ROS-mediated vascular endothelial progenitor cell damage and mitochondrial dysfunction via SIRT3/Foxo3 signaling pathway

    Journal of biochemical and molecular toxicology

More on Oxidative stress and ROS signaling

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