Long-chain chlorinated paraffins

1 paper5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funder: Natural Science Foundation of Jilin Province

Cells1

Outcomes

5

cGAS–STING signalling

upin cells1

1 study

Long-chain chlorinated paraffins activate cGAS–STING signalling in cells.
“which in turn activates the cGAS-STING pathway and ultimately drives granulosa cell senescence”
Cells
Long-chain chlorinated paraffins exposure induces premature ovarian failure by disrupting the balance of mitochondrial fission
Molecular and cellular biochemistry17 Aug 2026

More on cGAS–STING signalling

Mitochondrial fission and fusion

upin cells1

1 study

Long-chain chlorinated paraffins induce mitochondrial fission and fusion in cells.
“LCCPs induce excessive mitochondrial fission by blocking the interaction between Drp1 and Parkin”
Cells
Long-chain chlorinated paraffins exposure induces premature ovarian failure by disrupting the balance of mitochondrial fission
Molecular and cellular biochemistry17 Aug 2026

More on Mitochondrial fission and fusion

Primordial follicles

downin mice1

1 study

Long-chain chlorinated paraffins decrease primordial follicles in mice.
“In vivo exposure led to morphological degeneration of ovarian tissue and a reduction in the number of primordial follicles”
Animalsfemales
Long-chain chlorinated paraffins exposure induces premature ovarian failure by disrupting the balance of mitochondrial fission
Molecular and cellular biochemistry17 Aug 2026

Cellular senescence

upin cells1

1 study

Long-chain chlorinated paraffins increase cellular senescence in cells.
“significantly upregulating oxidative stress (MDA, ROS), inflammatory cytokines (IL-6, TNF-α), and aging markers (SA-β-gal activity)”
Cells
Long-chain chlorinated paraffins exposure induces premature ovarian failure by disrupting the balance of mitochondrial fission
Molecular and cellular biochemistry17 Aug 2026

More on Cellular senescence

Granulosa cell survival rate

downin cells1

1 study

Long-chain chlorinated paraffins decrease granulosa cell survival rate in cells (12%-58%).
“0.02-2 μg/mL of LCCPs concentration-dependently reduced granulosa cell survival rates (by 12%-58%, P < 0.05)”
Cells0.02-2 μg/mL
Long-chain chlorinated paraffins exposure induces premature ovarian failure by disrupting the balance of mitochondrial fission
Molecular and cellular biochemistry17 Aug 2026

More on Granulosa cell survival rate

Latest

1 in 12 months

Molecular and Cellular Biochemistry17 Aug

Long-chain chlorinated paraffins exposure induces premature ovarian failure by disrupting the balance of mitochondrial fission

Experiments in mouse cellsMitochondrial fission and fusion