Lmna mutation
Intervention1 paper1 finding
- Cells1
Outcomes
1Transcriptional ageing programs
upin human cells1
1 study
Transcriptional ageing programs
upin human cells1
Lmna mutation increases transcriptional ageing programs in human cells.
Cellsfollowing Progerin expressionProgerin expression
Nucleoli buffer displaced heterochromatin to limit premature aging programs in cells · bioRxiv · 1 Oct 2026 · Preprint
Latest
1CellsPreprint
Nucleoli buffer displaced heterochromatin to limit premature aging programs in cells
In cells expressing progerin, the nucleolus sequesters released lamina-associated domains to preserve gene repression and prevent worsening DNA damage.