NPM1 knockdown
Intervention1 paper2 findings
- Cells1
Outcomes
2Genomic instability
upin human cells1
1 study
Genomic instability
upin human cells1
NPM1 knockdown increases genomic instability in human cells.
Cellsunder Progerin expressiondepletion
Nucleoli buffer displaced heterochromatin to limit premature aging programs in cells · bioRxiv · 1 Oct 2026 · Preprint
H3K9me2
downin human cells1
1 study
H3K9me2
downin human cells1
NPM1 knockdown decreases H3K9me2 in human cells.
Cellsat relocated LADsdepletion
Nucleoli buffer displaced heterochromatin to limit premature aging programs in cells · bioRxiv · 1 Oct 2026 · Preprint
Latest
1CellsPreprint
Nucleoli buffer displaced heterochromatin to limit premature aging programs in cells
In cells expressing progerin, the nucleolus sequesters released lamina-associated domains to preserve gene repression and prevent worsening DNA damage.
bioRxiv · Mungo C et al.