LIPROXSTATIN-1

1. LIPROXSTATIN-1 decreases tubulointerstitial fibrosis in mice.

   “which attenuated aging-related renal injury including the apoptosis of renal cells, abnormal structures of GBM, and tubulointerstitial fibrosis.”

   Animalsin endothelial autophagy-deficient aged micekidney

   The Impairment of Endothelial Autophagy Accelerates Renal Senescence by Ferroptosis and NLRP3 Inflammasome Signaling Pathways with the Disruption of Endothelial Barrier

   Antioxidants (Basel, Switzerland)·Jul 23, 2024

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1. LIPROXSTATIN-1 inhibits ferroptosis in mice.

   “The pharmacologic inhibition of ferroptosis with liproxstatin-1 recovered the disrupted endothelial barrier and reversed the decreased expression of GPX4, as well as NLRP3 and IL-1β, in endothelial autophagy-deficient aged mice”

   Animalsin endothelial autophagy-deficient aged micekidney

   The Impairment of Endothelial Autophagy Accelerates Renal Senescence by Ferroptosis and NLRP3 Inflammasome Signaling Pathways with the Disruption of Endothelial Barrier

   Antioxidants (Basel, Switzerland)·Jul 23, 2024

More on Ferroptosis