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LINE1 aso-loaded sbp-engineered extracellular vesicles

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Nankai University and 3 more
  • Animals1

Outcomes

3

Senescence-associated secretory phenotype (SASP)

downin animals1

1 study

  1. LINE1 aso-loaded sbp-engineered extracellular vesicles inhibit senescence-associated secretory phenotype (SASP).

    “suppressing the expression of senescence-associated secretory phenotype (SASP) factors”

    Animalsmyocardial infarctionheart

    Delivering LINE1 antisense oligonucleotides via endothelial targeting extracellular vesicles to ameliorate myocardial infarction-induced cardiac senescence

    Bioactive materials8 Jul 2025

More on Senescence-associated secretory phenotype (SASP)

cGAS–STING signalling

downin animals1

1 study

  1. LINE1 aso-loaded sbp-engineered extracellular vesicles inhibit cGAS–STING signalling.

    “protect against myocardial senescence by inhibiting the cGAS-STING-TBK1-IRF3 pathway”

    Animalsmyocardial infarctionheart

    Delivering LINE1 antisense oligonucleotides via endothelial targeting extracellular vesicles to ameliorate myocardial infarction-induced cardiac senescence

    Bioactive materials8 Jul 2025

More on cGAS–STING signalling

Cellular senescence

downin animals1

1 study

  1. LINE1 aso-loaded sbp-engineered extracellular vesicles protect against cellular senescence.

    “The engineered EVs display targeted accumulation in injured hearts and protect against myocardial senescence by inhibiting the cGAS-STING-TBK1-IRF3 pathway and suppressing the expression of senescence-associated secretory phenotype (SASP) factors.”

    Animalsmyocardial infarctionheart

    Delivering LINE1 antisense oligonucleotides via endothelial targeting extracellular vesicles to ameliorate myocardial infarction-induced cardiac senescence

    Bioactive materials8 Jul 2025

More on Cellular senescence

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