LIN28A + tert + SH-P53

1. LIN28A + tert + SH-P53 decreases cellular senescence in human cells.

   “LTS treatment promoted self-renewal and rescued the pro-senescence phenotype of aged cachexia patients' muscle progenitors”

   Cellsin aged cachexia patients' muscle progenitors

   Adult progenitor rejuvenation with embryonic factors

   Cell proliferation·May 12, 2023

2. LIN28A + tert + SH-P53 inhibits cellular senescence in human cells.

   “a minimal combination of LIN28A, TERT, and sh-p53 (LTS), all of which are tightly regulated and play important roles during embryonic development, can delay senescence in adult muscle progenitors.”

   Cellsin adult muscle progenitors

   Adult progenitor rejuvenation with embryonic factors

   Cell proliferation·May 12, 2023

More on Cellular senescence

1. LIN28A + tert + SH-P53 improves muscle regeneration in humans.

   “promoted their engraftment for skeletal muscle regeneration in vivo.”

   Animalsaged cachexia patients' muscle progenitors

   Adult progenitor rejuvenation with embryonic factors

   Cell proliferation·May 12, 2023

1. LIN28A + tert + SH-P53 increases cell proliferation in human cells.

   “LTS muscle progenitors showed an extended proliferative capacity, maintained a normal karyotype, underwent myogenesis normally, and did not manifest tumorigenesis nor aberrations in lineage differentiation, even in late passages.”

   Cellsin late passages

   Adult progenitor rejuvenation with embryonic factors

   Cell proliferation·May 12, 2023