LIN28A

11 papers study it9 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

Includes the processes named after it and trials of drugs aimed at it.

4 independent labs in 2 countries
2 findings against

Funders: National Natural Science Foundation of China and others
1 of 8 findings with company ties

Animals4
Cells5

Effects

Pattern separation

upin mice2downin mice1

2 studies

LIN28A improves pattern separation in mice.
“Overexpression of Lin28a increased the proliferation of neural progenitor cells, promoted the functional integration of newborn neurons, restored neurogenesis in Wnt-deficient dentate gyrus, and rescued the impaired pattern separation in aging mice.”
Animalsin aging mice
Involvement of LIN28A in Wnt-dependent regulation of hippocampal neurogenesis in the aging brain
Stem cell reportsJun 23, 2022
LIN28A improves pattern separation in mice.
“Overexpression of Lin28a increased the proliferation of neural progenitor cells, promoted the functional integration of newborn neurons, restored neurogenesis in Wnt-deficient dentate gyrus, and rescued the impaired pattern separation in aging mice.”
AnimalsLin28a overexpression
A role for Lin28a in aging-associated decline of adult hippocampal neurogenesis
bioRxiv (Cold Spring Harbor Laboratory)Jan 4, 2022Preprint
LIN28A impairs pattern separation in mice.
“Loss of Lin28a inhibited the responsiveness of neural progenitor cells to niche Wnt agonist and reduced neurogenesis, thus impairing pattern separation.”
Animalsshown by loss of Lin28a
A role for Lin28a in aging-associated decline of adult hippocampal neurogenesis
bioRxiv (Cold Spring Harbor Laboratory)Jan 4, 2022Preprint

Neurogenesis

upin mice1downin mice1

1 study

LIN28A increases neurogenesis in mice.
“Overexpression of Lin28a increased the proliferation of neural progenitor cells, promoted the functional integration of newborn neurons, restored neurogenesis in Wnt-deficient dentate gyrus”
AnimalsLin28a overexpression in Wnt-deficient dentate gyrusdentate gyrus
A role for Lin28a in aging-associated decline of adult hippocampal neurogenesis
bioRxiv (Cold Spring Harbor Laboratory)Jan 4, 2022Preprint
LIN28A decreases neurogenesis in mice.
“Loss of Lin28a inhibited the responsiveness of neural progenitor cells to niche Wnt agonist and reduced neurogenesis”
Animalsshown by loss of Lin28ahippocampus
A role for Lin28a in aging-associated decline of adult hippocampal neurogenesis
bioRxiv (Cold Spring Harbor Laboratory)Jan 4, 2022Preprint

Platelet production

downin human cells1

1 study

LIN28A decreases platelet production in human cells.
“Overexpression of LIN28A upregulated immune-related signaling and diminished PLT production from imMKCLs.”
Cellsoverexpression in imMKCLs
STAT1-mediated epigenetic regulation of LIN28A controls iPSC-derived platelet production through the let-7-RALB axis
Blood advancesJun 17, 2025

Teratoma formation

downin P. model1−65%

1 study

LIN28A decreases teratoma formation in P. model (-65%).
“CRISPR-Lin28-edited iPSCs reducing teratoma formation by 65% in preclinical models.”
Reviewin preclinical models
Neuron Cell Culture and Its Obstacles: Challenges to Axon and Dendrite Growth and the Path Toward Neural Regeneration
Preprints.orgMar 31, 2025Preprint