Lifestyle factors

6 papers6 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 2 countries

Funder: Università degli Studi di Urbino Carlo Bo

Humans4
In silico1

Outcomes

Executive functions

upin humans1

1 study

Lifestyle factors improve executive functions in humans (higher than 65% of the sample).
“Individuals who adopted all four lifestyle behaviors exhibited executive function performance higher than 65% of the sample.”
Humans
Protecting the aging mind: how cognitive reserve and lifestyle factors relate to executive functions and long-term memory
Aging clinical and experimental research26 Mar 2026

Lifespan

upin silico1

1 study

Lifestyle factors extend lifespan in silico (at most ∼1 year).
“Our analysis predicts that lifestyle can extend maximal lifespan by at most ∼1 year”
In silicomodel prediction for lifestyle factors including exercise, nutrition, and sleep
Maximal human lifespan in light of a mechanistic model of aging
bioRxiv (Cold Spring Harbor Laboratory)23 Dec 2025Preprint

Cardiovascular biological age acceleration

downin humans1

1 study

Lifestyle factors decrease cardiovascular biological age acceleration in humans (β = -0.75, 95% CI: -0.77 to -0.73).
“Both the overall healthy lifestyle score and each of the 7 lifestyle factors were negatively associated with CBA acceleration (overall lifestyle score: β = -0.75, 95% CI: -0.77 to -0.73).”
Humansn = 251,478
Effects of Multiple Lifestyle Factors on Cardiovascular Biological Aging and Their Relative Contributions
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition20 Sep 2025

More on Cardiovascular biological age acceleration

Associations

Executive functions

upin humans1

1 study

Lifestyle factors predict executive functions in humans.
“lifestyle factors predicted executive functioning, while their association with long-term memory was limited.”
Humans
Protecting the aging mind: how cognitive reserve and lifestyle factors relate to executive functions and long-term memory
Aging clinical and experimental research26 Mar 2026

Chronic pain

mixedin humans1

1 study

Lifestyle factors are associated with chronic pain in humans.
“lifestyle factors such as sleep, stress, physical activity, and diet are increasingly recognized as modulators of both pain and immune function.”
Review
Exploring Chronic Pain, Immune Dysfunction and Lifestyle: A Focus on T Cell Exhaustion and Senescence
Biomolecules15 Nov 2025