Branched-chain amino acid restriction
6 papers13 findings
- 2 independent labs in 2 countries
- 3 findings against
- Funders: National Institute on Aging and others
- Animals5
Outcomes
6Cellular senescence
downin cells2upin mice2downin mice2
2 studies
Cellular senescence
downin cells2upin mice2downin mice2
Branched-chain amino acid restriction decreases cellular senescence in cells.
“lower levels of BCAAs protecting cultured cells from antimycin-A induced senescence.”
Cellsantimycin A-induced senescence
Aging cell28 Jul 2025
Branched-chain amino acid restriction increases cellular senescence in mice.
“potentiating cellular senescence in white adipose tissue.”
Animalswhite adipose tissue
Aging cell28 Jul 2025
Branched-chain amino acid restriction decreases cellular senescence in mice.
“restriction of all three BCAAs-but not individual BCAAs-protecting from hepatic cellular senescence”
Animalsliver
Aging cell28 Jul 2025
Branched-chain amino acid restriction inhibits cellular senescence in cells.
“lower levels of BCAAs protecting cultured cells from antimycin-A induced senescence”
Cellsantimycin-A-induced
bioRxiv : the preprint server for biology16 Jan 2025Preprint
Branched-chain amino acid restriction induces cellular senescence in mice.
“potentiating cell senescence in white adipose tissue”
Animalsrestriction of all three BCAAswhite adipose tissue
bioRxiv : the preprint server for biology16 Jan 2025Preprint
Branched-chain amino acid restriction inhibits cellular senescence in mice.
“restriction of all three BCAAs - but not individual BCAAs - protecting from hepatic cellular senescence”
Animalsrestriction of all three BCAAsliver
bioRxiv : the preprint server for biology16 Jan 2025Preprint
Metabolic health
upin mice2
2 studies
Metabolic health
upin mice2
Branched-chain amino acid restriction improves metabolic health in mice.
“reducing dietary levels of BCAAs protects male mice from the negative metabolic consequences of both normal and high protein diets.”
Animalsnormal and high protein dietsmales
Aging cell28 Jul 2025
Branched-chain amino acid restriction improves metabolic health in mice.
“reducing dietary levels of BCAAs protects male and female mice from the negative metabolic consequences of both normal and high protein diets”
Animalsin male and female mice on normal or high protein diets
bioRxiv : the preprint server for biology16 Jan 2025Preprint
Lifespan
no changein mice1upin mice1
1 study
Lifespan
no changein mice1upin mice1
Branched-chain amino acid restriction has no effect on lifespan in mice.
“leads to a 30% increase in lifespan and a reduction in frailty in male, but not female, wild-type mice when fed lifelong”
Animalslifelongfemales
Nature aging14 Jan 2021
Branched-chain amino acid restriction extends lifespan in mice.
“restricting dietary BCAAs increases the survival of two different progeroid mouse models”
Animalsprogeroid mouse models
Nature aging14 Jan 2021
Ovarian reserve
no changein mice1
1 study
Ovarian reserve
no changein mice1
Branched-chain amino acid restriction has no effect on ovarian reserve in mice.
“The BCAA restriction did not affect the ovarian reserve”
Animalsovaryfour monthsfemalesn = 9
Effects of calorie, protein, and branched chain amino acid restriction on ovarian aging in mice
Reproductive biology30 Jan 2024
Metabolic homeostasis
upin rodents1
1 study
Metabolic homeostasis
upin rodents1
Branched-chain amino acid restriction improves metabolic homeostasis in rodents.
“BCAAs and leucine (Leu) restriction promote metabolic homeostasis in rodents”
Reviewin rodents
Dietary protein and amino acid restriction: Roles in metabolic health and aging-related diseases
Free radical biology & medicine7 Dec 2021
Frailty
downin mice1
1 study
Frailty
downin mice1
Branched-chain amino acid restriction decreases frailty in mice.
“delays frailty and promotes the metabolic health of wild-type C57BL/6J mice when started in midlife”
Animals
Nature aging14 Jan 2021