Tryptophan restriction

1. Tryptophan restriction extends lifespan in rodents.

   “tryptophan (Trp) restriction extends the lifespan of rodents”

   Reviewin rodents

   Dietary protein and amino acid restriction: Roles in metabolic health and aging-related diseases

   Free radical biology & medicine·7 Dec 2021

2. Tryptophan restriction extends lifespan in Rodentia.

   “Reducing the tryptophan content of the diet extends maximum life span”

   Reviewin rodents

   Nutritional control of aging

   Experimental gerontology·1 Jan 2003

3. Tryptophan restriction extends lifespan in rats (36.31 ± 2.26 versus 30.5 ± 1.90 months (mean ± SEM)).

   “indicated an increase in their average lifespan at late ages.”

   Animalsafter recovery from long-term tryptophan restriction and refeedingtryptophan-deficient diet6–22 months of restriction

   Long-term tryptophan restriction and aging in the rat

   Aktuelle Gerontologie·1 Oct 1977

1. Tryptophan restriction increases inflammation in mice.

   “the Trp-restricted diet is reported to increase inflammation in aged mice”

   Review

   Dietary protein and amino acid restriction: Roles in metabolic health and aging-related diseases

   Free radical biology & medicine·7 Dec 2021

More on Inflammation

1. Tryptophan restriction increases gut microbial diversity in mice.

   “Dietary tryptophan restriction increased microbial diversity and made the gut microbiota composition of old Ercc1-/Δ7 mice more similar to that of young WT mice.”

   Animalsin old Ercc1-/Δ7 mice

   Frontline Science: Tryptophan restriction arrests B cell development and enhances microbial diversity in WT and prematurely aging Ercc1-/Δ7 mice

   Journal of leukocyte biology·14 Jul 2016

More on Gut microbial diversity

1. Tryptophan restriction inhibits B cell development in mice.

   “Dietary tryptophan restriction caused an arrest of B cell development in the BM, accompanied by diminished B cell frequencies in the periphery.”

   Animalsin WT and Ercc1-/Δ7 mice

   Frontline Science: Tryptophan restriction arrests B cell development and enhances microbial diversity in WT and prematurely aging Ercc1-/Δ7 mice

   Journal of leukocyte biology·14 Jul 2016

1. Tryptophan restriction decreases serotonin in mice.

   “Brain serotonin levels were significantly reduced only in mice on the tryptophan restricted diet”

   Animalsbrainup to 78 weeks

   Influence of diet on plasma tryptophan and brain serotonin levels in mice

   Experientia·15 Jan 1985

More on Serotonin

1. Tryptophan restriction decreases tryptophan in mice.

   “Plasma tryptophan levels were significantly reduced by both forms of dietary restriction.”

   Animalsplasmaup to 78 weeks

   Influence of diet on plasma tryptophan and brain serotonin levels in mice

   Experientia·15 Jan 1985

More on Tryptophan

1. Tryptophan restriction increases age at onset of visible tumors in rats.

   “showed a delay in the age of onset of visible tumors”

   Animalsafter refeedingtryptophan-deficient diet6–22 months of restriction

   Long-term tryptophan restriction and aging in the rat

   Aktuelle Gerontologie·1 Oct 1977

1. Tryptophan restriction improves recovery from hypothermia in rats.

   “They demonstrated an increased ability over similar aged controls to recover from hypothermia induced by 3-minute whole-body ice water immersion”

   Animalsafter refeeding; hypothermia induced by 3-minute whole-body ice water immersiontryptophan-deficient diet6–22 months of restriction

   Long-term tryptophan restriction and aging in the rat

   Aktuelle Gerontologie·1 Oct 1977

1. Tryptophan restriction is associated with reproductive ability at advanced ages in rats (Able to bear litters at 17–28 months).

   “were able to bear litters at 17--28 months of age”

   Animalsafter refeedingtryptophan-deficient diet6–22 months of restriction

   Long-term tryptophan restriction and aging in the rat

   Aktuelle Gerontologie·1 Oct 1977