Lactobacillus rhamnosus

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Animals1

Outcomes

4

PI3K–AKT signalling

downin mice1

1 study

Lactobacillus rhamnosus inhibits PI3K–AKT signalling in mice.
“LGG also reduced ADCK5, p-PI3K, and p-AKT levels.”
Animalsin OVA-induced asthmatic micelung
Lactobacillus rhamnosus regulates airway epithelial cell senescence through the ADCK5/PI3K/AKT signaling axis and alleviates airway inflammation in asthma
Naunyn-Schmiedeberg's archives of pharmacology12 Nov 2025

More on PI3K–AKT signalling

Oxidative stress and ROS signalling

downin mice1

1 study

Lactobacillus rhamnosus decreases oxidative stress and ROS signalling in mice.
“LGG can reduce ROS and γH2AX levels, increase MMP levels, improve mitochondrial structural damage”
Animalsin OVA-induced asthmatic micelung
Lactobacillus rhamnosus regulates airway epithelial cell senescence through the ADCK5/PI3K/AKT signaling axis and alleviates airway inflammation in asthma
Naunyn-Schmiedeberg's archives of pharmacology12 Nov 2025

More on Oxidative stress and ROS signalling

Cellular senescence

downin mice1

1 study

Lactobacillus rhamnosus decreases cellular senescence in mice.
“reduced the number of SA-β-gal-positive cells and P21 and P16 expression”
Animalsin OVA-induced asthmatic micelung
Lactobacillus rhamnosus regulates airway epithelial cell senescence through the ADCK5/PI3K/AKT signaling axis and alleviates airway inflammation in asthma
Naunyn-Schmiedeberg's archives of pharmacology12 Nov 2025

More on Cellular senescence

Airway hyperresponsiveness

upin mice1

1 study

Lactobacillus rhamnosus improves airway hyperresponsiveness in mice.
“LGG improved AHR levels in OVA-induced asthmatic mice”
Animalsin OVA-induced asthmatic mice
Lactobacillus rhamnosus regulates airway epithelial cell senescence through the ADCK5/PI3K/AKT signaling axis and alleviates airway inflammation in asthma
Naunyn-Schmiedeberg's archives of pharmacology12 Nov 2025

Latest

1 in 12 months

Naunyn-Schmiedeberg's Archives of Pharmacology12 Nov

Lactobacillus rhamnosus regulates airway epithelial cell senescence through the ADCK5/PI3K/AKT signaling axis and alleviates airway inflammation in asthma

Experiments in miceAsthma