Ketotifen

1. Ketotifen improves lysosome in mice.

   “a five-month oral course of ketotifen, an approved H1-antihistamine and mast-cell stabiliser, re-acidifies lysosomes in aged C57BL/6J male mice”

   Animalsoralfive-monthmales

   Targeting lysosomal acidification to restore microglial homeostasis and mitigate memory decline during male brain ageing

   Brain, behavior, and immunity·4 Nov 2025

1. Ketotifen decreases inflammation in mouse cells.

   “ketotifen attenuates lipopolysaccharide-evoked release of TNF-α, IL-1β and IL-10 in vitro and ex vivo”

   Cellslipopolysaccharide-evoked

   Targeting lysosomal acidification to restore microglial homeostasis and mitigate memory decline during male brain ageing

   Brain, behavior, and immunity·4 Nov 2025

More on Inflammation

1. Ketotifen increases SYNAPTOPHYSIN in mice.

   “Ketotifen robustly elevates cortical synaptophysin and PSD-95 above age-matched levels.”

   Animalsoralcortexfive-monthmales

   Targeting lysosomal acidification to restore microglial homeostasis and mitigate memory decline during male brain ageing

   Brain, behavior, and immunity·4 Nov 2025

More on SYNAPTOPHYSIN

1. Ketotifen improves spatial learning and object-location memory in mice.

   “ketotifen enhances spatial learning and object-location memory without altering locomotor activity or anxiety-like behaviour”

   Animalsoralbrainfive-monthmales

   Targeting lysosomal acidification to restore microglial homeostasis and mitigate memory decline during male brain ageing

   Brain, behavior, and immunity·4 Nov 2025

1. Ketotifen decreases mast cell hypertrophy in mice.

   “five months of ketotifen treatment reversed these morphometric alterations toward a youthful profile.”

   Animalsbrainfive months

   Ketotifen reacidifies secretory lysosomes and normalises ageing phenotypes in mast cells

   Biochemical and biophysical research communications·29 Oct 2025

1. Ketotifen decreases mast cell expansion in mice.

   “Chronic ketotifen treatment restored and amplified the quinacrine signal, enlarged granules, and reduced late-life MC expansion.”

   Animalsin aged miceperitoneal mast cells

   Ketotifen reacidifies secretory lysosomes and normalises ageing phenotypes in mast cells

   Biochemical and biophysical research communications·29 Oct 2025

1. Ketotifen increases lysosomal acidification in mice.

   “Chronic ketotifen treatment restored and amplified the quinacrine signal, enlarged granules, and reduced late-life MC expansion.”

   Animalsin aged miceperitoneal mast cells

   Ketotifen reacidifies secretory lysosomes and normalises ageing phenotypes in mast cells

   Biochemical and biophysical research communications·29 Oct 2025

1. Ketotifen protects against skin aging.

   “The use of novel MC stabilisers such as ketotifen or luteolin, as well as phototherapy and other treatments, shows potential in mitigating skin aging”

   Review

   The Role of Mast Cells in Skin Aging: Mechanisms and Therapeutic Advances

   Experimental dermatology·29 Oct 2025