Isothiocyanates
Isothiocyanates has been studied in 9 papers since 2015: 1 observational study in people, 8 reviews; 4 in the past year. It has not reached trials in people. The newest paper, Mar 25, 2026: “Biochemical pathways linking adiposity, diet, and endometrial carcinogenesis”.
See all 9 papers on isothiocyanates
- Humans1
What did studies of isothiocyanates find?
4Studies of isothiocyanates measured 4 outcomes, among them NRF2–KEAP1 antioxidant response, apoptosis and autophagy.
NRF2–KEAP1 antioxidant response
upin humans1upin reviews1
2 studies
NRF2–KEAP1 antioxidant response
upin humans1upin reviews1
Isothiocyanates activate NRF2–KEAP1 antioxidant response.
“recognized as potent inducers of mammalian cytoprotective responses via the KEAP1/NRF2 pathway”
Review
Therapeutic potential of isothiocyanates by targeting the NRF2 pathway
Free radical biology & medicine
Isothiocyanates activate NRF2–KEAP1 antioxidant response in humans.
“In humans, ITCs activate nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated detoxification, induce apoptosis, and modulate epigenetic pathways.”
Reviewin humans
Nutrients
Apoptosis
upin humans1
1 study
Apoptosis
upin humans1
Isothiocyanates induce apoptosis in humans.
“In humans, ITCs activate nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated detoxification, induce apoptosis, and modulate epigenetic pathways.”
Reviewin humans
Nutrients
Autophagy
upin reviews1
1 study
Autophagy
upin reviews1
Isothiocyanates induce autophagy.
“Additionally, ITCs have been shown to induce autophagy, a critical cellular process that reduces the accumulation of damaged proteins and age-related aggregates, thereby supporting cellular health.”
Review
Isothiocyanates from cruciferous plants as geroprotectors
Advances in pharmacology (San Diego, Calif.)
Cancer cell viability
downin humans1
1 study
Cancer cell viability
downin humans1
Isothiocyanates inhibit cancer cell viability in humans.
“In a dose dependent manner, ITC inhibits the viability of human cancer cells”
Review
The antioxidant properties of organosulfur compounds (sulforaphane)
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