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Insulin-like growth factor-i

Intervention

2 papers3 findings

MeSH

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Heart, Lung, and Blood Institute and 2 more
  • Animals2

Outcomes

3

DNA content

upin rats1

1 study

  1. Insulin-like growth factor-i increases DNA content in rats.

    “Administration of IGF-I increased the aortic DNA content in all but the oldest rats.”

    Animalsaorta1.2 mg/kg/day2 weeksmales

    Effect of age and IGF-I administration on elastin gene expression in rat aorta

    Journal of gerontology1 Jul 1990

More on DNA content

Insoluble elastin

upin rats1

1 study

  1. Insulin-like growth factor-i increases insoluble elastin in rats.

    “Administration of IGF-I increased aortic elastin synthesis throughout the life span of the rat”

    Animalsaorta1.2 mg/kg/day2 weeksmales

    Effect of age and IGF-I administration on elastin gene expression in rat aorta

    Journal of gerontology1 Jul 1990

More on Insoluble elastin

Tropoelastin mRNA

upin rats1

1 study

  1. Insulin-like growth factor-i increases tropoelastin mRNA in rats.

    “Administration of IGF-I elevated aortic tropoelastin mRNA steady-state levels”

    Animalsaorta1.2 mg/kg/day2 weeksmales

    Effect of age and IGF-I administration on elastin gene expression in rat aorta

    Journal of gerontology1 Jul 1990

More on Tropoelastin mRNA

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