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In vitro expansion

Exposure

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Cells1

Outcomes

1

Replicative capacity

downin human cells1

1 study

  1. In vitro expansion decreases replicative capacity in human cells (Losses equivalent to about half the total replicative lifespan).

    “even protocols that involve minimal expansion induce a rapid aging of MSCs, with losses equivalent to about half their total replicative lifespan.”

    Cellseven with minimal expansionbone marrow stromal cell

    Study of telomere length reveals rapid aging of human marrow stromal cells following in vitro expansion

    Stem cells (Dayton, Ohio)1 Jan 2004

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