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IGF1 neutralizing antibody

Intervention

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Humans1

Outcomes

1

Cellular senescence

downin mouse cells1

1 study

  1. IGF1 neutralizing antibody decreases cellular senescence in mouse cells.

    “Blocking IGF1 signaling with a neutralizing antibody reduced the number of senescent AT2 cells”

    CellsYAP activation in fibroblasts

    YAP/TAZ activation in fibroblasts coordinates fibrotic remodeling, fibroinflammation, and epithelial dysfunction in pulmonary fibrosis

    bioRxiv (Cold Spring Harbor Laboratory)25 Jun 2025Preprint

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