Hypoxia-reoxygenation

Intervention

2 findings

  • 1 lab

Outcomes

2

CDC6

upin human cells1

1 study
  1. Hypoxia-reoxygenation increases CDC6 in human cells.

    “Quantitative proteomic analysis identified CDC6 as a prominently upregulated protein under H/R conditions.”

    Cellshypoxia/reoxygenation

    CDC6 promotes keratinocyte senescence through the CCND1/P53 signaling in ischemia-reperfusion injury-induced pressure injury

    Experimental cell research22 Jan 2026

More on CDC6

Cellular senescence

upin human cells1

1 study
  1. Hypoxia-reoxygenation induces cellular senescence in human cells.

    “H/R induction significantly exacerbated the senescence response, as characterized by reduced cell proliferation, increased apoptosis, elevated SA-β-galactosidase (SA-β-gal) activity, and upregulated expression of senescence markers (p16 and p21).”

    Cellshypoxia/reoxygenation

    CDC6 promotes keratinocyte senescence through the CCND1/P53 signaling in ischemia-reperfusion injury-induced pressure injury

    Experimental cell research22 Jan 2026

More on Cellular senescence