CDC6

4 papers5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

1 lab

Animals1
Cells3

Interventions

Hypoxia-reoxygenation

upin human cells1

1 study

Hypoxia-reoxygenation increases CDC6 in human cells.
“Quantitative proteomic analysis identified CDC6 as a prominently upregulated protein under H/R conditions.”
Cellshypoxia/reoxygenation
CDC6 promotes keratinocyte senescence through the CCND1/P53 signaling in ischemia-reperfusion injury-induced pressure injury
Experimental cell research22 Jan 2026

Effects

TP53

upin human cells1

1 study

CDC6 increases TP53 in human cells.
“siRNA-mediated CDC6 knockdown attenuated keratinocyte senescence, restored G1/S phase cyclin-D1 (CCND1) expression, and suppressed p53 levels, demonstrating its regulatory role in senescence via the p53/CCND1 pathway.”
Cellshypoxia/reoxygenation, shown by siRNA knockdown
CDC6 promotes keratinocyte senescence through the CCND1/P53 signaling in ischemia-reperfusion injury-induced pressure injury
Experimental cell research22 Jan 2026

Associations

COVID-19 pneumonia

upin silico1

1 study

COVID-19 pneumonia is associated with CDC6 in silico.
“re-analysis of publicly available single-cell RNA-sequencing datasets from COVID pneumonia patients revealed elevated CDC6 expression alongside reduced MYC and ODC1 levels”
In silicoin alveolar epithelial cells exhibiting markers of senescence
Putrescine functions as a metabolic checkpoint in replication stress-induced senescence
Cellular and molecular life sciences : CMLS19 Nov 2025