Hypoxia-preconditioned bone marrow mesenchymal stem cell-derived exosomes

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Animals1

Outcomes

Cellular senescence

downin rat cells1

1 study

Hypoxia-preconditioned bone marrow mesenchymal stem cell-derived exosomes decrease cellular senescence in rat cells.
“Hypo-BMSCs-Exos exerted superior effects in suppressing inflammatory responses, apoptosis, ECM degradation, and cellular senescence in rat chondrocytes”
Cellsin IL-1β-induced rat chondrocytes
Hypoxia-preconditioned bone marrow mesenchymal stem cell-derived exosomes ameliorate knee osteoarthritis by promoting cartilage regeneration and alleviating pain in rats
Regenerative therapy30 Nov 2025

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Regenerative Therapy23 Dec