Human umbilical cord mesenchymal stromal cell-derived exosomes

1. Human umbilical cord mesenchymal stromal cell-derived exosomes decrease CRAT K141bhb in mice.

   “We validated carnitine acetyltransferase (CRAT) K141bhb as an age-accumulated modification reversed by exosomes in an AMPKα2- associated manner.”

   AnimalsAMPKα2-associated effectheart

   Cell-derived particles improved heart function in some aged mice

   Molecular & cellular proteomics : MCP·Oct 15, 2026

More on CRAT K141bhb

1. Human umbilical cord mesenchymal stromal cell-derived exosomes decrease aging-elevated lysine β-hydroxybutyrylation in mice.

   “Site-level analysis revealed that exosomes selectively normalized Kbhb sites elevated during aging, whereas AMPKα2 deficiency caused nonselective global depletion.”

   Animalsheart

   Cell-derived particles improved heart function in some aged mice

   Molecular & cellular proteomics : MCP·Oct 15, 2026

More on Aging-elevated lysine β-hydroxybutyrylation

1. Human umbilical cord mesenchymal stromal cell-derived exosomes improve mitochondrial ultrastructure in mice.

   “In AMPKα2-knockout aged (AKA) mice, exosomes partially improved mitochondrial ultrastructure and diastolic indices but did not rescue systolic function or fibrosis.”

   AnimalsAMPKα2-knockout miceheart

   Cell-derived particles improved heart function in some aged mice

   Molecular & cellular proteomics : MCP·Oct 15, 2026

1. Human umbilical cord mesenchymal stromal cell-derived exosomes decrease cardiac fibrosis in mice.

   “In wild-type aged (WTA) mice, hUCMSC-exos improved systolic and diastolic function, enhanced grip strength, reduced fibrosis, and restored ATP levels”

   Animalswild-type miceheart

   Cell-derived particles improved heart function in some aged mice

   Molecular & cellular proteomics : MCP·Oct 15, 2026

1. Human umbilical cord mesenchymal stromal cell-derived exosomes improve grip strength in mice.

   “In wild-type aged (WTA) mice, hUCMSC-exos improved systolic and diastolic function, enhanced grip strength, reduced fibrosis, and restored ATP levels”

   Animalswild-type mice

   Cell-derived particles improved heart function in some aged mice

   Molecular & cellular proteomics : MCP·Oct 15, 2026

1. Human umbilical cord mesenchymal stromal cell-derived exosomes improve systolic and diastolic function in mice.

   “In wild-type aged (WTA) mice, hUCMSC-exos improved systolic and diastolic function”

   Animalswild-type miceheart

   Cell-derived particles improved heart function in some aged mice

   Molecular & cellular proteomics : MCP·Oct 15, 2026