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Human platelet lysate

Intervention

2 papers7 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 2 independent labs in 2 countries
  • Funders: Cancer Prevention and Research Institute of Texas and 5 more
  • Animals1
  • Cells1

Outcomes

6

Cellular senescence

downin human cells2

2 studies

  1. Human platelet lysate decreases cellular senescence in human cells.

    “HPL-expanded CAR Vδ2 T cells exhibited reduced apoptosis and senescence transcriptional pathways compared to FBS-expanded CAR-Vδ2 T cells”

    Cellscompared to FBS-expanded CAR-Vδ2 T cells

    Human platelet lysate enhances in vivo activity of CAR-Vδ2 T cells by reducing cellular senescence and apoptosis

    Cytotherapy12 Mar 2024

  2. Human platelet lysate decreases cellular senescence in human cells.

    “The senescent cells were significantly decreased in ADSCs cultured in an HPL-coated plate”

    Cellsadipose tissue

    The Use of Human Platelet Lysate as a Coating Substance for Adipose-Derived Stem Cell Expansion

    Frontiers in bioscience (Landmark edition)23 Feb 2024

More on Cellular senescence

Telomerase activity

upin human cells1

1 study

  1. Human platelet lysate increases telomerase activity in human cells.

    “increased telomerase activity.”

    Cellscompared to FBS-expanded CAR-Vδ2 T cells

    Human platelet lysate enhances in vivo activity of CAR-Vδ2 T cells by reducing cellular senescence and apoptosis

    Cytotherapy12 Mar 2024

More on Telomerase activity

Apoptosis

downin human cells1

1 study

  1. Human platelet lysate decreases apoptosis in human cells.

    “HPL-expanded CAR Vδ2 T cells exhibited reduced apoptosis and senescence transcriptional pathways compared to FBS-expanded CAR-Vδ2 T cells”

    Cellscompared to FBS-expanded CAR-Vδ2 T cells

    Human platelet lysate enhances in vivo activity of CAR-Vδ2 T cells by reducing cellular senescence and apoptosis

    Cytotherapy12 Mar 2024

More on Apoptosis

Cell expansion

upin human cells1

1 study

  1. Human platelet lysate increases cell expansion in human cells.

    “HPL supported greater expansion of CAR-Vδ2 T cells with comparable in vitro cytotoxicity and cytokine secretion to FBS-expanded CAR-Vδ2 T cells.”

    Cellscompared with FBS-expanded counterparts

    Human platelet lysate enhances in vivo activity of CAR-Vδ2 T cells by reducing cellular senescence and apoptosis

    Cytotherapy12 Mar 2024

Cell growth

upin human cells1

1 study

  1. Human platelet lysate increases cell growth in human cells.

    “shortened population doubling time, and stimulated cell growth”

    Cellsadipose tissue

    The Use of Human Platelet Lysate as a Coating Substance for Adipose-Derived Stem Cell Expansion

    Frontiers in bioscience (Landmark edition)23 Feb 2024

Cell adhesion

upin human cells1

1 study

  1. Human platelet lysate increases cell adhesion in human cells.

    “ADSCs cultured on HPL-coated plates significantly increased cell adhesion rate”

    Cellsadipose tissue

    The Use of Human Platelet Lysate as a Coating Substance for Adipose-Derived Stem Cell Expansion

    Frontiers in bioscience (Landmark edition)23 Feb 2024

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