Human adipose stem cell-derived exosomes
1 paper studies it3 findings
- 1 lab in 1 country
- Funders: Kaohsiung Medical University and 1 more
- Animals1
Outcomes
2Glycosaminoglycan
upin human cells1
1 study
Glycosaminoglycan
upin human cells1
Human adipose stem cell-derived exosomes increase glycosaminoglycan in human cells.
“hypoxia-ADSC-Exos had the best effect on GAG formation in normal HACs rather than those cultured in normoxia or hypoxia plus 2% de-Exo-FBS.”
Cellsin normal HACs
International journal of molecular sciencesAug 29, 2023
Senescence-associated secretory phenotype (SASP)
downin human cells1
1 study
Senescence-associated secretory phenotype (SASP)
downin human cells1
Human adipose stem cell-derived exosomes inhibit senescence-associated secretory phenotype (SASP) in human cells.
“hypoxia-ADSC-Exos alleviated the harmful effect in OA-like HACs by decreasing markers of normal cartilage (GAG and type II collagen) and increasing markers of fibrous or degenerative cartilage”
Cellsin OA-like HACs in vitro
International journal of molecular sciencesAug 29, 2023
Associations
1Osteoarthritis
downin rats1
1 study
Osteoarthritis
downin rats1
Human adipose stem cell-derived exosomes lower the risk of osteoarthritis in rats.
“intra-articular treatment with hypoxia-ADSC-Exos suppressed OA progression, as evidenced by the weight-bearing function test and cartilage GAG quantification in ACLT rats.”
Animalsin ACLT-induced OA ratsintra-articular injection
International journal of molecular sciencesAug 29, 2023
Latest
International Journal of Molecular Sciences
Exosomes Derived from Hypoxia-Cultured Human Adipose Stem Cells Alleviate Articular Chondrocyte Inflammaging and Post-Traumatic Osteoarthritis Progression
Experiments in ratsOsteoarthritis