HOTAIRM1 gene therapy

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: National Natural Science Foundation of China and 1 more

Animals1

Outcomes

Cellular proliferation

upin mice1

1 study

HOTAIRM1 gene therapy increases cellular proliferation in mice.
“In aged mouse lungs, adeno-associated virus-mediated HOTAIRM1 overexpression reduced fibrosis, alleviated tissue damage, and promoted cellular proliferation, underscoring its therapeutic potential.”
Animalsadeno-associated virus-mediated overexpressionlung
Multiomic single-cell perturbation screens reveal critical lncRNA regulators of senescence
Nature aging31 Mar 2026

Lung tissue damage

downin mice1

1 study

HOTAIRM1 gene therapy decreases lung tissue damage in mice.
“In aged mouse lungs, adeno-associated virus-mediated HOTAIRM1 overexpression reduced fibrosis, alleviated tissue damage, and promoted cellular proliferation, underscoring its therapeutic potential.”
Animalsadeno-associated virus-mediated overexpressionlung
Multiomic single-cell perturbation screens reveal critical lncRNA regulators of senescence
Nature aging31 Mar 2026

Pulmonary fibrosis

downin mice1

1 study

HOTAIRM1 gene therapy decreases pulmonary fibrosis in mice.
“In aged mouse lungs, adeno-associated virus-mediated HOTAIRM1 overexpression reduced fibrosis, alleviated tissue damage, and promoted cellular proliferation, underscoring its therapeutic potential.”
Animalsadeno-associated virus-mediated overexpressionlung
Multiomic single-cell perturbation screens reveal critical lncRNA regulators of senescence
Nature aging31 Mar 2026

Latest

1 in 12 months

Nature Aging31 Mar

Multiomic single-cell perturbation screens reveal critical lncRNA regulators of senescence

Experiments in miceInterventions

Paper

HOTAIRM1 gene therapy

Outcomes

Latest

Multiomic single-cell perturbation screens reveal critical lncRNA regulators of senescence

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