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Nature Aging·31 Mar

Multiomic single-cell perturbation screens reveal critical lncRNA regulators of senescence

Experiments in miceInterventions

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Cellular senescence1
Chromatin1
Chromatin and 3D genome organisation1
DNA damage response1
DNA repair1
Epigenetic regulation of gene expression1
HOTAIRM11
TP531
Cellular proliferation1
Chromatin accessibility1
HOTAIRM1 gene therapy1
p53–p21 pathway1
Pulmonary fibrosis1

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Trials

AKG and Brain Health in AgingPhase 2Registered 6 Oct 2026, University of Oklahoma Safety and Preliminary Efficacy of Adipose-Derived Stem Cell Secretome in Frailty (VinVital)Phase 1Registered 2 Oct 2026, Vinmec Research Institute of Stem Cell and Gene Technology AI-Based Conversational Social Support for Older Adults With Heart FailureRegistered 7 Oct 2026, Chang Gung University of Science and Technology

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Mechanisms246 Interventions460 Biomarkers437 Populations604 AI & data171 Industry & policy23

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