GW4869

1. GW4869 increases muscle fibre cross-sectional area in mice (404.0 ± 5.15 μm2 vs. 172.0 ± 5.39 μm2).

   “increased grip strength (222.4 ± 15.91 g vs. 159.2 ± 11.65 g, p < 0.001) and muscle fibre cross-sectional area (404.0 ± 5.15 μm2 vs. 172.0 ± 5.39 μm2, p < 0.001)”

   Animalsin cigarette smoke-exposed mice

   Cigarette Smoke-Exposed Alveolar Epithelial Cell-Derived Exosomes Exacerbate Skeletal Muscle Dysfunction Through HDAC2 Signalling

   Journal of cachexia, sarcopenia and muscle·20 Jul 2026

1. GW4869 improves grip strength in mice (222.4 ± 15.91 g vs. 159.2 ± 11.65 g).

   “GW4869 treatment ameliorated CS-induced muscle dysfunction in mice, as evidenced by increased grip strength (222.4 ± 15.91 g vs. 159.2 ± 11.65 g, p < 0.001)”

   Animalsin cigarette smoke-exposed mice

   Cigarette Smoke-Exposed Alveolar Epithelial Cell-Derived Exosomes Exacerbate Skeletal Muscle Dysfunction Through HDAC2 Signalling

   Journal of cachexia, sarcopenia and muscle·20 Jul 2026

1. GW4869 prevents depressive-like behavior in mice.

   “Pharmacologic exosomes inhibition (GW4869) prevented both molecular and behavioral phenotypes”

   Animalsin MIA arthritis mice

   Exosomes from joints mediate depressive-like behaviors in MIA arthritis mice

   Brain research bulletin·8 May 2026

1. GW4869 protects against osteoporosis in mice.

   “skeletal muscle-targeted delivery of GW4869 significantly restored osteoblast activity and alleviated bone loss in aged mice.”

   Animalsduring agingbone

   Atrophic Skeletal Muscle-Derived Extracellular Vesicles Transfer miR-125a-5p to Inhibit Bone Formation in Osteoporosis during Aging

   Advanced science (Weinheim, Baden-Wurttemberg, Germany)·26 Feb 2026

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