GFD-CD3
Intervention1 paper3 findings
- Animals1
Outcomes
2Senescent cells
downin mice1downin non-human primates1Very low certainty
1 study
Senescent cells
downin mice1downin non-human primates1Very low certainty
GFD-CD3 decreases senescent cells in non-human primates.
“low-dose GFD-CD3 effectively eliminated senescent cells and alleviated age-related pathologies in aged mice and non-human primates without adverse effects.”
Animalslow-dose, transaminase-guided monitoring
Bispecific T cell engager eliminates senescent cells in mice and nonhuman primates · Aging cell · 29 Sep 2026
GFD-CD3 decreases senescent cells in mice.
“low-dose GFD-CD3 effectively eliminated senescent cells and alleviated age-related pathologies in aged mice and non-human primates without adverse effects.”
Animalslow-dose, transaminase-guided monitoring
Bispecific T cell engager eliminates senescent cells in mice and nonhuman primates · Aging cell · 29 Sep 2026
Hepatotoxicity
upin mice1Very low certainty
1 study
Hepatotoxicity
upin mice1Very low certainty
GFD-CD3 induces hepatotoxicity in mice.
“high-dose GFD-CD3 predominantly induced hepatotoxicity through T cell-mediated attack on hepatic endothelial cells.”
Animalshigh-doseliver
Bispecific T cell engager eliminates senescent cells in mice and nonhuman primates · Aging cell · 29 Sep 2026
Latest
1Bispecific T cell engager eliminates senescent cells in mice and nonhuman primates
Monitored by serum transaminase levels, low doses of the drug alleviated age-related pathologies without causing the hepatotoxicity seen at higher…Monitored by serum transaminase levels, low doses of the drug alleviated age-related pathologies without causing the hepatotoxicity seen at higher doses.