Gamma-secretase inhibitor

1. Gamma-secretase inhibitor decreases cellular senescence in human cells (matrix stiffness-induced senescence).

   “treatment with an FDA-approved γ-secretase inhibitor attenuates stiffness-induced senescence”

   Cellsmatrix stiffness-induced senescenceendothelial cells

   Stiffer gels prompt aging-related changes in human vessel cells

   Advanced science (Weinheim, Baden-Wurttemberg, Germany)·Jul 2, 2026

2. Gamma-secretase inhibitor decreases cellular senescence in mice (Notch blockade during liver regeneration).

   “Blocking the Notch by γ-secretase inhibitor (GSI) diminished senescence and promoted LSEC expansion.”

   AnimalsNotch blockade during liver regenerationliver sinusoidal endothelial cells

   Shear stress-induced cellular senescence blunts liver regeneration through Notch-sirtuin 1-P21/P16 axis

   Hepatology (Baltimore, Md.)·Dec 7, 2021

More on Cellular senescence

1. Gamma-secretase inhibitor increases neuron-specific cholesterol-synthesis gene expression in human cells (via lowered neuronal cholesterol).

   “which in turn stimulates neuron-specific cholesterol-synthesis gene expression”

   Cellsvia lowered neuronal cholesterol

   Neuronal γ-secretase regulates lipid metabolism, linking cholesterol to synaptic dysfunction in Alzheimer's disease

   Neuron·Aug 4, 2023

1. Gamma-secretase inhibitor decreases cholesterol in human cells (chronic suppression; neurons compared with glia).

   “chronic γ-secretase suppression robustly decreases cholesterol levels in neurons but not in glia”

   Cellschronic suppression; neurons compared with glia

   Neuronal γ-secretase regulates lipid metabolism, linking cholesterol to synaptic dysfunction in Alzheimer's disease

   Neuron·Aug 4, 2023

More on Cholesterol

1. Gamma-secretase inhibitor increases synapse number in human cells (chronic suppression).

   “chronic pharmacological or genetic suppression of γ-secretase increases synapse numbers”

   Cellschronic suppression

   Neuronal γ-secretase regulates lipid metabolism, linking cholesterol to synaptic dysfunction in Alzheimer's disease

   Neuron·Aug 4, 2023

1. Gamma-secretase inhibitor decreases synaptic transmission in human cells (chronic suppression).

   “decreases synaptic transmission by lowering the presynaptic release probability”

   Cellschronic suppression

   Neuronal γ-secretase regulates lipid metabolism, linking cholesterol to synaptic dysfunction in Alzheimer's disease

   Neuron·Aug 4, 2023

More on Synaptic transmission

1. Gamma-secretase inhibitor increases osteogenic differentiation in mouse cells (Restored to a normal level).

   “After the aged BMSCs being treated with γ-secretase inhibitor, however, Notch activity was changed and the aging-imparied osteogenic ability reverted to a normal level.”

   Cellsbone marrow mesenchymal stem cells

   γ-Secretase inhibitor reverts the Notch signaling attenuation of osteogenic differentiation in aged bone marrow mesenchymal stem cells

   Cell biology international·Jan 24, 2016