Advanced Science
Stiffer gels prompt aging-related changes in human vessel cells
In a three-dimensional lab model, human blood-vessel-forming cells developed senescence signs after 48 hours in stiffened gels without added inflammatory signals.In a three-dimensional lab model, human blood-vessel-forming cells developed senescence signs after 48 hours in stiffened gels without added inflammatory signals.
Human cell studyMechanisms
Who was studiedHuman endothelial colony-forming cells, 48 hours, against cells in soft gels
What changedHuman vessel-forming cells showed more aging-related changes in stiffened gels than in soft gels
The catchObservation lasted only 48 hours after stiffening