Galangin

1. Galangin inhibits DPP4–NOX1 interaction in mouse cells.

   “Mechanistically, galangin inhibited DPP4 nuclear translocation and disrupted its interaction with NADPH oxidase NOX1”

   Cellsbone marrow stromal cell

   DPP4-Driven Ferroptosis Promotes Senescence: Galangin as a Therapeutic Agent for Age-Related Bone Loss

   Drug development research·27 Apr 2026

1. Galangin inhibits DPP4 nuclear translocation in mouse cells.

   “Mechanistically, galangin inhibited DPP4 nuclear translocation and disrupted its interaction with NADPH oxidase NOX1”

   Cellsbone marrow stromal cell

   DPP4-Driven Ferroptosis Promotes Senescence: Galangin as a Therapeutic Agent for Age-Related Bone Loss

   Drug development research·27 Apr 2026

1. Galangin improves osteogenic differentiation capacity in mouse cells.

   “Galangin suppressed ferroptosis, rescued senescence phenotypes, and restored osteogenic differentiation capacity.”

   CellsSenescent BMSCbone marrow stromal cell

   DPP4-Driven Ferroptosis Promotes Senescence: Galangin as a Therapeutic Agent for Age-Related Bone Loss

   Drug development research·27 Apr 2026

1. Galangin inhibits ferroptosis in mouse cells.

   “Galangin suppressed ferroptosis, rescued senescence phenotypes, and restored osteogenic differentiation capacity.”

   CellsSenescent BMSCbone marrow stromal cell

   DPP4-Driven Ferroptosis Promotes Senescence: Galangin as a Therapeutic Agent for Age-Related Bone Loss

   Drug development research·27 Apr 2026

More on Ferroptosis

1. Galangin decreases cellular senescence in mouse cells.

   “Galangin suppressed ferroptosis, rescued senescence phenotypes, and restored osteogenic differentiation capacity.”

   CellsSenescence induced by d-galactose or serial passagingbone marrow stromal cell

   DPP4-Driven Ferroptosis Promotes Senescence: Galangin as a Therapeutic Agent for Age-Related Bone Loss

   Drug development research·27 Apr 2026

More on Cellular senescence

1. Galangin decreases bone loss in mice.

   “Galangin significantly attenuated bone loss and reduced senescence markers in both aging mouse models.”

   AnimalsNatural aging and d-galactose-induced aging modelsbone

   DPP4-Driven Ferroptosis Promotes Senescence: Galangin as a Therapeutic Agent for Age-Related Bone Loss

   Drug development research·27 Apr 2026