Fap inhibitor

Intervention

1 paper2 findings

  • 1 lab in 1 country
  • Funders: National Natural Science Foundation of China and 3 more
  • Animals1

Outcomes

2

Inflammation

downin mice1

1 study
  1. Fap inhibitor decreases inflammation in mice (p < 0.0001).

    “Pharmacological inhibition of FAP, both in vitro and in vivo, effectively attenuated periodontal inflammation, suppressed osteoclast activity (p < 0.0001), and preserved alveolar bone integrity in aging mice (p < 0.0001).”

    Animalsin aging mice

    Inhibiting fibroblast activation protein mitigates aging-related periodontitis by blocking nuclear factor kappa B-mediated osteoclastogenesis

    International immunopharmacology12 Apr 2026

More on Inflammation

Periodontitis

downin mice1

1 study
  1. Fap inhibitor protects against periodontitis in mice (p < 0.0001).

    “Pharmacological inhibition of FAP, both in vitro and in vivo, effectively attenuated periodontal inflammation, suppressed osteoclast activity (p < 0.0001), and preserved alveolar bone integrity in aging mice (p < 0.0001).”

    Animalsin aging mice

    Inhibiting fibroblast activation protein mitigates aging-related periodontitis by blocking nuclear factor kappa B-mediated osteoclastogenesis

    International immunopharmacology12 Apr 2026

More on Periodontitis

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