Fap inhibitor
1 paper2 findings
- 1 lab in 1 country
- Funders: National Natural Science Foundation of China and 3 more
- Animals1
Outcomes
2Inflammation
downin mice1
1 study
Inflammation
downin mice1
Fap inhibitor decreases inflammation in mice (p < 0.0001).
“Pharmacological inhibition of FAP, both in vitro and in vivo, effectively attenuated periodontal inflammation, suppressed osteoclast activity (p < 0.0001), and preserved alveolar bone integrity in aging mice (p < 0.0001).”
Animalsin aging mice
International immunopharmacology12 Apr 2026
Periodontitis
downin mice1
1 study
Periodontitis
downin mice1
Fap inhibitor protects against periodontitis in mice (p < 0.0001).
“Pharmacological inhibition of FAP, both in vitro and in vivo, effectively attenuated periodontal inflammation, suppressed osteoclast activity (p < 0.0001), and preserved alveolar bone integrity in aging mice (p < 0.0001).”
Animalsin aging mice
International immunopharmacology12 Apr 2026
Latest
1 in 12 monthsInternational Immunopharmacology
Inhibiting fibroblast activation protein mitigates aging-related periodontitis by blocking nuclear factor kappa B-mediated osteoclastogenesis
Experiments in miceMechanisms