Gal@sd + fap@bd

Intervention

1 paper2 findings

  • 1 lab in 1 country
  • Funders: Guangdong Provincial Pearl River Talents Program and 3 more
  • Animals1

Outcomes

2

Respiratory function

upin mice1

1 study
  1. Gal@sd + fap@bd improves respiratory function in mice.

    “improved respiratory function, reduced collagen deposition, and reversal of fibrosis-associated transcriptional programs.”

    Animalsin bleomycin-induced pulmonary fibrosisnanococktail (GAL@SD and FAP@BD)lung

    Inhalable Polymeric PROTAC Nanococktail for Targeted Protein Degradation in Idiopathic Pulmonary Fibrosis

    Journal of the American Chemical Society24 Jun 2026

Collagen deposition

downin mice1

1 study
  1. Gal@sd + fap@bd decreases collagen deposition in mice.

    “In a bleomycin-induced mouse model of pulmonary fibrosis, the combined PROTAC nanococktail achieves superior therapeutic efficacy compared with either single PROTAC nanoparticle, as demonstrated by restored lung architecture, improved respiratory function, reduced collagen deposition”

    Animalsin bleomycin-induced pulmonary fibrosisnanococktail (GAL@SD and FAP@BD)lung

    Inhalable Polymeric PROTAC Nanococktail for Targeted Protein Degradation in Idiopathic Pulmonary Fibrosis

    Journal of the American Chemical Society24 Jun 2026

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