Gal@sd + fap@bd
1 paper2 findings
- 1 lab in 1 country
- Funders: Guangdong Provincial Pearl River Talents Program and 3 more
- Animals1
Outcomes
2Respiratory function
upin mice1
1 study
Respiratory function
upin mice1
Gal@sd + fap@bd improves respiratory function in mice.
“improved respiratory function, reduced collagen deposition, and reversal of fibrosis-associated transcriptional programs.”
Animalsin bleomycin-induced pulmonary fibrosisnanococktail (GAL@SD and FAP@BD)lung
Journal of the American Chemical Society24 Jun 2026
Collagen deposition
downin mice1
1 study
Collagen deposition
downin mice1
Gal@sd + fap@bd decreases collagen deposition in mice.
“In a bleomycin-induced mouse model of pulmonary fibrosis, the combined PROTAC nanococktail achieves superior therapeutic efficacy compared with either single PROTAC nanoparticle, as demonstrated by restored lung architecture, improved respiratory function, reduced collagen deposition”
Animalsin bleomycin-induced pulmonary fibrosisnanococktail (GAL@SD and FAP@BD)lung
Journal of the American Chemical Society24 Jun 2026
Latest
1 in 12 monthsJournal of the American Chemical Society
Inhalable Polymeric PROTAC Nanococktail for Targeted Protein Degradation in Idiopathic Pulmonary Fibrosis
Experiments in miceIdiopathic pulmonary fibrosis