Extracellular vesicles from human induced pluripotent stem cell-derived neural stem cells

1. Extracellular vesicles from human induced pluripotent stem cell-derived neural stem cells inhibit cGAS–STING signalling in mice.

   “hiPSC-NSC-EVs therapy decreased the levels of various proteins involved in the activation of the NLRP3 inflammasome, p38/mitogen-activated protein kinase, cGAS-STING-IFN-1, and Janus kinase and signal transducer and activator of transcription signalling pathways.”

   Animalsextracellular vesicleshippocampustwo intranasal doses

   Intranasal Human NSC-Derived EVs Therapy Can Restrain Inflammatory Microglial Transcriptome, and NLRP3 and cGAS-STING Signalling, in Aged Hippocampus

   Journal of extracellular vesicles·1 Feb 2026

More on cGAS–STING signalling

1. Extracellular vesicles from human induced pluripotent stem cell-derived neural stem cells inhibit NLRP3 inflammasome in mice.

   “hiPSC-NSC-EVs therapy decreased the levels of various proteins involved in the activation of the NLRP3 inflammasome, p38/mitogen-activated protein kinase, cGAS-STING-IFN-1, and Janus kinase and signal transducer and activator of transcription signalling pathways.”

   Animalsextracellular vesicleshippocampustwo intranasal doses

   Intranasal Human NSC-Derived EVs Therapy Can Restrain Inflammatory Microglial Transcriptome, and NLRP3 and cGAS-STING Signalling, in Aged Hippocampus

   Journal of extracellular vesicles·1 Feb 2026

More on NLRP3 inflammasome

1. Extracellular vesicles from human induced pluripotent stem cell-derived neural stem cells decrease oxidative stress and ROS signalling in mice.

   “hippocampus of animals receiving hiPSC-NSC-EVs exhibited reductions in astrocyte hypertrophy, microglial clusters, and oxidative stress”

   Animalsextracellular vesicleshippocampustwo intranasal doses

   Intranasal Human NSC-Derived EVs Therapy Can Restrain Inflammatory Microglial Transcriptome, and NLRP3 and cGAS-STING Signalling, in Aged Hippocampus

   Journal of extracellular vesicles·1 Feb 2026

More on Oxidative stress and ROS signalling

1. Extracellular vesicles from human induced pluripotent stem cell-derived neural stem cells improve cognitive function in mice.

   “These changes mediated by hiPSC-NSC-EVs were also associated with improved cognitive and memory function.”

   Animalsextracellular vesicleshippocampustwo intranasal doses

   Intranasal Human NSC-Derived EVs Therapy Can Restrain Inflammatory Microglial Transcriptome, and NLRP3 and cGAS-STING Signalling, in Aged Hippocampus

   Journal of extracellular vesicles·1 Feb 2026