Resistance training + essential amino acids
Resistance training + essential amino acids has been studied in 2 papers since 2022: 1 trial in people, 1 in animals; 1 in the past year. The newest paper, Mar 21, 2026: “Combined resistance exercise and essential amino acid intake enhance follistatin/myostatin ratio and muscle fitness in older women: a randomized controlled trial”.
2 papers study it11 findingsUpdated
See all 2 papers on resistance training + essential amino acids
At a glance
The findings reach people, from one lab or study. 2 independent labs in 1 country.
“Two-way repeated-measures ANOVA demonstrated significant group-by-time interaction effects for muscle mass (F(3, 72) = 5.042, p = 0.003, partial η2 = 0.174) and BMI (F(3, 72) = 3.248, p = 0.027, partial η2 = 0.119).”
None of its findings points the other way.
- 2 independent labs in 1 country
- Funders: National Research Foundation of Korea and 6 more
- 3 of 11 findings with company ties
- Human trial1
- Animals1
Studies in people
1 study gave resistance training + essential amino acids to people and measured what changed.
| What changed | Design | People | Source |
|---|---|---|---|
up: Increases muscle masspartial η2 = 0.174 up: Improves muscle fitnesspartial η2 = 0.198 up: Increases follistatin/myostatin ratio+113.94% | Randomized trial12 weeks | 96 peoplewomen72.8 ± 4.57 yearsElderly women | Journal of the International Society of Sports Nutrition, Mar 21, 2026 |
What did studies of resistance training + essential amino acids find?
9Studies of resistance training + essential amino acids measured 9 outcomes, among them follistatin/myostatin ratio, muscle mass and TNF-alpha.
Follistatin/myostatin ratio
upin humans1+114%
1 study
Follistatin/myostatin ratio
upin humans1+114%
Resistance training + essential amino acids increase follistatin/myostatin ratio in humans (compared with control and EAA groups) (F(3, 72) = 5.556, p = 0.002, partial η2 = 0.188).
“The follistatin/myostatin ratio increased most in the RE + EAA group (F(3, 72) = 5.556, p = 0.002, partial η2 = 0.188)”
Human trialcompared with control and EAA groups12 weeksfemales
Journal of the International Society of Sports Nutrition
Resistance training + essential amino acids increase follistatin/myostatin ratio in humans (+113.94%).
“Post-hoc comparisons demonstrated that the RE + EAA group exhibited a significantly greater increase in the ratio compared with both the CON (p < 0.001) and EAA groups (p < 0.05).”
Human trial12 weeksfemalesn = 96
Journal of the International Society of Sports Nutrition
Muscle mass
upin humans1
1 study
Muscle mass
upin humans1
Resistance training + essential amino acids increase muscle mass in humans (F(3, 72) = 5.042, p < 0.001, partial η2 = 0.174).
“The RE + EAA group demonstrated a significant increase in muscle mass (F(3, 72) = 5.042, p < 0.001, partial η2 = 0.174)”
Human trial12 weeksfemales
Journal of the International Society of Sports Nutrition
Resistance training + essential amino acids increase muscle mass in humans (partial η2 = 0.174).
“Two-way repeated-measures ANOVA demonstrated significant group-by-time interaction effects for muscle mass (F(3, 72) = 5.042, p = 0.003, partial η2 = 0.174) and BMI (F(3, 72) = 3.248, p = 0.027, partial η2 = 0.119).”
Human trial12 weeksfemalesn = 96
Journal of the International Society of Sports Nutrition
TNF-alpha
downin humans1
1 study
TNF-alpha
downin humans1
Resistance training + essential amino acids decrease TNF-alpha in humans (RE + EAA group only).
“whereas TNF-α decreased only in the RE + EAA group (p < 0.05)”
Human trialRE + EAA group only12 weeksfemales
Journal of the International Society of Sports Nutrition
Senior Fitness Test
upin humans1
1 study
Senior Fitness Test
upin humans1
Resistance training + essential amino acids improve senior Fitness Test in humans (p ranging from <0.05 to <0.001).
“greater improvements in the senior fitness test (p ranging from < 0.05 to < 0.001)”
Human trial12 weeksfemales
Journal of the International Society of Sports Nutrition
Inflammation
downin humans1
1 study
Inflammation
downin humans1
Resistance training + essential amino acids decrease inflammation in humans (partial η2 = 0.108).
“Two-way repeated-measures ANOVA revealed a significant group-by-time interaction for IL-6 (F(3, 72) = 2.909, p = 0.040, partial η2 = 0.108), and significant main effects of time for IL-6 (F(1, 72) = 12.444, p < 0.001, partial η2 = 0.147), IL-1β (F(1, 72) = 3.992, p = 0.050, partial η2 = 0.053), and TNF-α (F(1, 72) = 9.869, p = 0.002, partial η2 = 0.121”
Human trial12 weeksfemalesn = 96
Journal of the International Society of Sports Nutrition
Muscle fitness
upin humans1
1 study
Muscle fitness
upin humans1
Resistance training + essential amino acids improve muscle fitness in humans (partial η2 = 0.198).
“Two-way repeated-measures ANOVA demonstrated significant group-by-time interaction effects for the 30-sec chair stand (F(3, 72) = 2.834, p = 0.044, partial η2 = 0.106), 2-minute step (F(3, 72) = 5.083, p = 0.003, partial η2 = 0.175), Timed Up & Go (F(3, 72) = 5.911, p = 0.001, partial η2 = 0.198), and F8WT (F(3, 72) = 5.601, p = 0.002, partial η2 = 0.189”
Human trial12 weeksfemalesn = 96
Journal of the International Society of Sports Nutrition
Mitochondrial biogenesis (PGC-1α)
upin mice1
1 study
Mitochondrial biogenesis (PGC-1α)
upin mice1
Resistance training + essential amino acids increase mitochondrial biogenesis (PGC-1α) in dexamethasone-treated mice.
“improvements in myofibrillar protein synthesis, NMJ, fiber type preservation, and/or mitochondrial biogenesis”
Animalsin dexamethasone-treated mice
International journal of molecular sciences
Endurance
upin mice1
1 study
Endurance
upin mice1
Resistance training + essential amino acids improve endurance in dexamethasone-treated mice.
“EAA and RET synergistically improve muscle mass and/or strength, and endurance capacity”
Animalsin dexamethasone-treated mice
International journal of molecular sciences
Muscle strength
upin mice1
1 study
Muscle strength
upin mice1
Resistance training + essential amino acids improve muscle strength in dexamethasone-treated mice.
“EAA and RET synergistically improve muscle mass and/or strength”
Animalsin dexamethasone-treated mice
International journal of molecular sciences