Epacadostat

1 paper2 findings

1 lab

Cells1

Outcomes

2

Senescence-associated changes

downin human cells1

1 study

Epacadostat decreases senescence-associated changes in human cells.
“epacadostat attenuated osteogenic impairment and senescence-associated changes.”
CellsPorphyromonas gingivalis lipopolysaccharide exposureosteoblast
Porphyromonas gingivalis lipopolysaccharide induces osteoblast senescence and defective mineralization associated with indoleamine 2,3-dioxygenase 1-kynurenine-aryl hydrocarbon receptor signaling
Life sciences14 Oct 2026

Osteogenic impairment

downin human cells1

1 study

Epacadostat decreases osteogenic impairment in human cells.
“epacadostat attenuated osteogenic impairment and senescence-associated changes.”
CellsPorphyromonas gingivalis lipopolysaccharide exposureosteoblast
Porphyromonas gingivalis lipopolysaccharide induces osteoblast senescence and defective mineralization associated with indoleamine 2,3-dioxygenase 1-kynurenine-aryl hydrocarbon receptor signaling
Life sciences14 Oct 2026

Latest

1 in 12 months

Life Sciences4 h

Porphyromonas gingivalis lipopolysaccharide induces osteoblast senescence and defective mineralization associated with indoleamine 2,3-dioxygenase 1-kynurenine-aryl hydrocarbon receptor signaling

Experiments in human cellsTryptophan–kynurenine metabolism