IDO1 promoter activity

1. RELA increases IDO1 promoter activity in cells.

   “RELA overexpression enhanced wild-type IDO1 promoter activity, with loss of this response after mutation of the predicted NF-κB site.”

   CellsRELA overexpression; response lost after mutation of the predicted NF-κB site

   Porphyromonas gingivalis lipopolysaccharide induces osteoblast senescence and defective mineralization associated with indoleamine 2,3-dioxygenase 1-kynurenine-aryl hydrocarbon receptor signaling

   Life sciences·14 Oct 2026

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