Enterococcus faecalis

1. Enterococcus faecalis extends lifespan in worms (+33.55% average lifespan).

   “enhance the average lifespan of C. elegans by 33.55%”

   Model organisms

   Enterococcus faecalis SI-FC-01 enhances the stress resistance and healthspan of C. elegans via AKT signaling pathway

   Scientific reports·Apr 25, 2025

2. Enterococcus faecalis has no effect on lifespan in flies.

   “supplementation of media with Enterococcus faecalis did not alter adult female life span in the presence or absence of mifepristone.”

   Model organismswith or without mifepristonefemales

   Mifepristone Increases Life Span in Female Drosophila Without Detectable Antibacterial Activity

   Frontiers in aging·Jul 22, 2022

1. Enterococcus faecalis activates PI3K–AKT signaling in worms.

   “E. faecalis SI-FC-01 modulates DAF-16/FOXO signaling via the activation of AKT pathway”

   Model organismsin C. elegans

   Enterococcus faecalis SI-FC-01 enhances the stress resistance and healthspan of C. elegans via AKT signaling pathway

   Scientific reports·Apr 25, 2025

More on PI3K–AKT signaling

1. Enterococcus faecalis protects against Parkinson's disease in worms.

   “exhibited neuroprotective effects in the worm models of neurodegenerative diseases such as Parkinson's disease and Huntington's disease”

   Model organismsin worm models of Parkinson's disease and Huntington's disease

   Enterococcus faecalis SI-FC-01 enhances the stress resistance and healthspan of C. elegans via AKT signaling pathway

   Scientific reports·Apr 25, 2025

More on Parkinson's disease

1. Enterococcus faecalis improves healthspan in worms.

   “enhanced the motor ability, memory and learning ability and anti-oxidative stress ability of C. elegans”

   Model organisms

   Enterococcus faecalis SI-FC-01 enhances the stress resistance and healthspan of C. elegans via AKT signaling pathway

   Scientific reports·Apr 25, 2025

1. Enterococcus faecalis decreases fat degeneration in mice.

   “These results indicated pathologic improvement, such as suppression of fat degeneration in the liver.”

   Animalsliverfrom 10 weeks to 1.5 years of age

   Dysfunction of the Murine Liver with Aging and Its Improvement with the Continuous Consumption of Enterococcus faecalis EC-12

   Nutrients·Jun 26, 2024